Alex's Lemonade Stand Foundation for Childhood Cancer

Alex’s Lemonade Stand Foundation (ALSF) for Childhood Cancer today announced the awarding of nearly $4 million in new pediatric cancer research grants. The medical grants will extend to 18 institutions and universities in 13 states across the country, totaling 26 new grants. The Foundation is dedicated to continuing the development and testing of new treatments as well as the improvement of availability of clinical trials, and most importantly finding cures for all childhood cancers.

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Innovation Awards 2009

Children’s Hospital of Boston, Boston, MA
Investigating the role of lin-28 in germ cell tumorigenesis
Dr. George Daley

Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Epigenetic manipulation of leukemia
Dr. H. Leighton Grimes

Duke University, Durham, NC
Metabolic control of p53 activation in T-ALL
Dr. Jeffrey Rathmell

Duke University, Durham, NC
Modeling anaplastic medulloblastoma using cerebellar stem cells
Dr. Robert Wechsler-Reya

Georgetown University, Washington, DC
Targeted regulation of acetylation as novel therapy for Ewing's sarcoma
Dr. Jeffrey Toretsky

Huntsman Cancer Institute, Salt Lake City, UT
Molecular diagnostic, prognostic, and therapeutic approaches toward Ewing's sarcoma
Dr. Stephen Lessnick

Memorial Sloan-Kettering Cancer Center, New York, NY
Linking mitogenic sonic hedgehog signaling to the oncogene Yap 1 in neural stem/progenitor cells and medulloblastoma
Dr. Anna Kenney

The Children’s Hospital of Philadelphia, Philadelphia, PA
Pharmacogenomics of childhood AML susceptibility and treatment response
Dr. Richard Aplenc

The Children’s Hospital of Philadelphia, Philadelphia, PA
BH3 profiling to define therapy resistance classes in neuroblastoma
Dr. Michael Hogarty

University of Rochester, Rochester, NY
Adaptation of acute lymphoblastic leukemia (ALL) to the post-transplant allogeneic environment
Dr. Craig Mullen

Vanderbilt University Medical Center, Nashville, TN
Targeting wnt in synovial sarcoma models
Dr. Josiane Eid

Program Infrastructure Awards 2009

Children’s Hospital of Denver, Aurora, CO
Expanding access to new agents for children with refractory cancers: the experimental therapeutics program at Children's Hospital of Colorado
Dr. Lia Gore

Dana-Farber Cancer Institute, Boston, MA
Development of a childhood leukemia translational research program
Dr. Lewis Silverman

The Children’s Hospital of Philadelphia, Philadelphia, PA
Biology-based clinical trials for children with cancer
Dr. Rochelle Bagatell

Vanderbilt University Medical Center, Nashville, TN
Pediatric oncology translational research program
Dr. James Whitlock

Young Investigator Awards 2009

Cancer Research Center of Hawaii, Honolulu, HI
DFMO-based combination therapy for the treatment of advanced stage neuroblastoma
Dr. Dana-Lynn Koomoa

Children’s Mercy, Kansas City, MO
MLL-based chromosomal translocations in the pathogenesis of childhood leukemia
Dr. Erin Guest

Children’s National Medical Center, Washington, DC
Immune stimulatory antigen loaded particles (ISAPS) for the treatment of solid childhood tumors
Dr. Suzanne Miles

Dana-Farber Cancer Institute, Boston, MA
Identification of proteins interacting with ALK in neuroblastoma
Dr. Rani George

Dana-Farber Cancer Institute, Boston, MA
Genetic regulators of ER stress-induced apoptosis in pediatric malignancies
Dr. Ujwal Pyati

Fred Hutchinson Cancer Research Center
Aberrant DNA methylation in Ewing’s sarcoma
Dr. Scott Borinstein

Huntsman Cancer Institute, Salt Lake City, UT
GSTM4, a novel target for treating Ewing's sarcoma
Dr. Wen Luo

Massachusetts General Hospital, Boston, MA
Identification of FDA approved drugs with anti-tumor activity in rhabdomyosarcoma
Dr. David Langenau

The Johns Hopkins University School of Medicine, Baltimore, MD
Exploring a novel immunotherapy: cooperation of endogenous CD8+ t-cells and exogenous, allogeneic CD4+ t-cells
Dr. Heather Symons

University of California San Francisco, San Francisco, CA
Identifying novel biomarkers for risk stratification in t-cell acute lymphoblastic leukemia(ALL)
Dr. Michelle Hermiston

University of California San Francisco, San Francisco, CA
Optimizing EGFR targeted therapy in pediatric malignant glioma
Dr. Theodore Nicolaides

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