Earlier in 2021, Alex’s Lemonade Stand Foundation committed $18.5 million to four game-changing, collaborative projects at 15 institutions in the United States and Europe. Funded through the Crazy 8 Initiative, these projects are taking on the most deadly childhood cancers with one singular focus: curing the incurable. In September, the four project teams gathered at the Crazy 8 Summit, a two-day virtual event in which the scientists shared, collaborated and challenged each other. ALSF asked the researchers to be bold and dream big with game changing ideas. In just a few months of work, these four interdisciplinary teams have already made significant progress, setting the stage for discoveries that are already changing the way the research community understands pediatric cancer.