Alex's Lemonade Stand Foundation Blog

For childhood cancer researchers, publishing in a scientific journal is not just about the prestige and accomplishment. Publishing is one of the key ways scientists can collaborate and move closer to breakthroughs and cures for children. 

“The purpose of research is the generation of new knowledge. If research is kept private and placed in a drawer then it is useless,” said Dr. Adolfo Ferrando of Columbia University, who published his research about a mutation that drives the relapse of acute lymphoblastic leukemia (ALL) in the January 2018 edition of Nature. “By publishing, we give the clinical community the opportunity to use the published knowledge.”

Published research can also foster new research projects by inspiring new ways of looking at the same problem or influence studies across disciplines. Publication also gets scientists talking and offering meaningful feedback that can make the next phase of research even better and more effective. 

ALSF has been credited in hundreds of published articles since funding that first research grant in 2005. Now 800 research grants later, the Foundation funding even more cutting-edge science and fostering collaboration between researchers. 

Researchers often publish when they’ve made a breakthrough—one that could spur more breakthroughs for childhood cancer researchers everywhere. Here are three ALSF researchers who made and published landmark discoveries this year:

Dr. Adolfo Ferrando, Columbia University 

After Dr. Ferrando identified a mutation prevalent in some types of hard-to-treat leukemia, he wanted to push his research farther and prove that the mutation was the very thing that drove children to relapse with the disease. Using funding through the ALSF Innovation Grant program, Dr. Ferrando was able to fully study the mutation, called NT5C2, and make a critical discovery: chemotherapy, which typically pushes a child with acute lymphoblastic leukemia (ALL) into remission, was actually promoting cancer cell growth in leukemia with this type of mutation. 

Essentially, the treatment for some children was the cause for others. 

Dr. Ferrando’s breakthrough research appeared in Nature magazine, a prestigious scientific journal that is widely read by other pediatric cancer researchers everywhere.

The implications are both short and long-term. In the short-term, children battling ALL could be tested and monitored for NT5C2. This would allow doctors to predict the likelihood of relapse and make treatment decisions that were more likely to lead to remission. In the long-term, scientists can use this information to test drugs that could inhibit NT5C2 and stop it from powering leukemia cell growth. 

Dr. Steven DuBois, Dana-Farber Cancer Institute

Dr. DuBois, who works on the Dana-Farber team funded through the ALSF Center of Excellence Grant program, led a clinical trial testing the safety and effectiveness of larotrectinib, a drug that showed effectiveness in the inhibition of a protein that drives the development of certain rare childhood and adult cancers, including infantile fibrosarcoma, a rare type of soft tissue cancer. 

The results of his study were astounding: over 75% of patients treated with larotectinib responded positively to the drug and their tumors either disappeared or shrunk. His research, published in The New England Journal of Medicine in February, shares critical details of his work and gives other clinicians additional treatment options for their patients battling cancer.

“Our goal is to make discoveries and disseminate these discoveries, especially when there is a therapy with such a high response rate and tolerability,” said Dr. DuBois. 

Dr. Steven Jonas, UCLA

Dr. Jonas, an engineer, oncologist and scientist, created a potentially time-saving and cost-efficient way to deliver childhood cancer treatments using nanotechnology. Nanotechnology refers to working with materials that are on the scale of a nanometer, which is the thickness of a piece of human hair sliced down 100,000 times. 

He and his interdisciplinary group of chemists, engineers, and physician-scientists are building nanorobotic, gene-delivery drones to deploy genes and gene-editing packages directly to cells quickly, safely and for a lower cost than current delivery methods. Dr. Jonas published the results of his research in the March 2018 edition of ACS Nano.

For kids battling cancer, this “tiny” technology has the potential to significantly reduce the wait time for delivery of precision medicine, like CAR T-immunotherapy.

“The opportunity to continue to explore 'outside the box' ideas like this and move toward defeating childhood cancer once and for all with emerging cellular therapies has added so much to my pediatric oncology fellowship training and informed the next stage of my academic career and research,” said Dr. Jonas.


Learn the story behind the Alex's Lemonade Days and Alex's Original Stand for childhood cancer.

Back where it all began. ALSF Founder Alex Scott, above, at one of her lemonade stands. 

by Trish Adkins

It all started with one front yard lemonade stand. 

ALSF Founder Alex Scott had one big idea: to host lemonade stands to help other kids just like her feel better. When Alex was just 4-years-old, she hosted her first lemonade stand. That first stand kept growing each year and four years later, when Alex was 8-years-old, her lemonade stand raised $1 million for childhood cancer research.

The last stand that Alex would attend was held at her elementary school, Penn Wynne Elementary School in Wynnewood, Pennsylvania.  Penn Wynne still hosts Alex’s “Original” Lemonade Stand on a Saturday in early June. This year, Alex's "Original" kicks off Lemonade Days –a full week of supporter lemonade stands hosted in front yards, at schools, businesses and in communities all across the country. 

We spoke with Alex’s parents about the early days of Alex’s Lemonade Stand Foundation and how Alex’s “Original” got its start. 

What are the origins of Alex’s big idea for a lemonade stand?

Alex was 3-years-old and after many sit-downs with the doctors who offered us little hope, we heard of another doctor and an experimental treatment at Children’s Hospital of Philadelphia (CHOP). We made the trip and after Alex finished the treatment, she told us it had worked. She knew she felt better. Alex felt so good and I guess that gave her the idea that there was more to be done as far as research went.  

We got home and Alex said just randomly, “Can I have a lemonade stand?” I didn’t think much of the request. It was the wintertime and it was cold outside, so I just told her we could when it got warmer.

Alex kept asking. First, it was once a month, then once a week, then eventually once a day. Finally, Liz asked her “What is it you want to buy so badly?”

And when you asked her what she wanted, what did she say?

She said she did not want anything. Alex said she wanted to help her doctors help kids like they had helped her. I was proud of her. But honestly, I thought it was adorable that she thought she could solve a big problem like cancer with a simple thing like a lemonade stand. 

Tell me about building her original stand. 

Her first stand was just a little plastic kid-sized picnic table, one pitcher of lemonade and some handmade posters that Liz and the kids had made. It was nothing elaborate or that required a lot of time to build. We still tell people today that they can certainly build a stand if they want, but they do not have to – it can be as simple as a decorated table!

What was that first stand like?

We had her first stand in Connecticut before we moved to Philadelphia. Friends and family showed up and remarkably, total strangers came as well. We were blown away by the generosity of people and shocked that Alex was able to raise $2,000 with her stand that day. When I tucked her in at night, she told me that it was the best thing that ever happened to her. I knew then that it was really important to her – more than I had realized.  

It was amazing, people came, some with smiles, some with tears, but they kept coming and coming! I had never seen anything like it before -- certainly not a lemonade stand like that before.  

What did Alex want you to do with the money?

For the first few years of her stand, we donated it to neuroblastoma research at her hospital, since she was battling neuroblastoma herself that made sense to me. One day, Alex asked me what we were doing with the money and when I told her, she said “That is so selfish. All kids want their tumors to go away. We should be giving to all hospitals for all kinds of kids' cancers.” 

I knew then that she was right; this was not about finding a cure for her. It was about truly making a difference for all kids with cancer.  

How did Alex’s Lemonade Days evolve?

Alex’s first stand was held in our front yard in Connecticut. Then, when we moved the Philadelphia area in 2001, Alex had all of her stands in our neighborhood outside of Philadelphia. The Philadelphia Inquirer ran a story on her second Philly stand in 2002 and that is when things really started to take off. People started sending money to her from all over the country and they were holding their own lemonade stands as well.   

Alex kept holding stands in our front yard. Each year, she raised more money and her efforts were growing and growing. However, by 2004 the experimental treatments had stopped working. That is when Alex became even more determined to change things for other kids with cancer – she wanted to have one last stand and she set a goal of raising $1 million! When we asked her how she would raise a million dollars with a lemonade stand, she said, “If everyone has lemonade stands, I think we can do it.” That was the beginning of Lemonade Days—Alex really created that event.  


It was incredible how people answered Alex’s call to action. Alex was on the Today show and so many other news outlets. They were contacting us and telling us they were going to hold a lemonade stand. On the same day as her last stand, there were stands all across the country and donations flooded in. She was able to reach her goal by mid-July 2004 (with big help from Volvo*, who took her over her goal with a big donation). She passed away just 2 weeks later on August 1st — and I am so grateful that her final goal was met, that she was able to see the incredible support. I like to think that she knew it would continue without her, until the day when all children with cancer are cured.  

Each year, Alex's “Original” Stand is held at Penn Wynne Elementary School? Why is the school so important to the Foundation?

When Alex was alive, Penn Wynne Elementary was her school. All 3 of her brothers have also attended, and we live just two blocks from it, so it is personally important to our family. The staff and families gave Alex and our family unconditional support. When Alex’s stand had outgrown our front yard, the principal of the school offered to move it to the school. This was the perfect place to hold her last stand—right in our neighborhood with all of our friends. After Alex passed away, the school continued to support our family in upholding her annual lemonade stand tradition.  

Even though our kids no longer attend Penn Wynne as they have moved on to middle school, high school, college and beyond,  we are amazed at the support the school community still shows for Alex’s cause. The kids love it and their families come out to support the stand even though they never knew Alex or our family. 

What is the energy like at Alex’s “Original” Lemonade Stand?

It is a great day; so much fun for families with so many activities and things go do. But mixed into the fun are many reminders all day long of why we are doing it.  There are childhood cancer hero families who attend, we have a butterfly release to remember Alex and all children with cancer, and of course, photos of Alex and a beautiful wishing garden.  

We set up one of Alex’s lemonade stands. That small stand, amidst all the bigness of the event at Penn Wynne, reminds us how everyone can make a difference. That is the lesson that Alex taught us and curing childhood cancer is the job she left for us. 

Everyone wants their child to be successful in life. And Alex was successful. Her legacy and her dreams are coming true. We see it when we read the amazing scientific breakthroughs that our grants are making possible. We feel it when families tell us how ALSF helped them get to treatment. Alex’s “Original” is a celebration of where we came from and where we will go.

Attend Alex’s “Original” Lemonade Stand! and join  Lemonade Days!
Appropriately named Alex’s “Original” Lemonade Stand, Alex’s friends and family continue to hold her stand which has evolved into a family fun event complete with food, games, crafts, face-painting, music, raffle baskets and (of course) lemonade, held at the school Alex attended, Penn Wynne Elementary School.

Amidst the fun is a beautiful butterfly release to commemorate and celebrate the lives of all children fighting cancer as well as those who have lost their life to the disease. In addition, Alex’s parents and brothers attend the event as well as several other childhood cancer heroes and their families.  If you can't make Alex's "Original," stop by a lemonade stand in your community or sign-up to host your own during Lemonade Days or any day!  Use our Lemonade Stand Finder to find one near you. 


Alex Scott

guest post by Terry McCarthy, host of Light Lemons (the lemonade stand held by Lightfoot, Franklin & White) 

A couple years ago, I was asked to give the commencement address to the graduating class at Cumberland School of Law. It was both thrilling and terrifying at the same time. As I thought about what to say in the speech, dozens of ideas popped into my mind, but none of them seemed right. I am an adjunct faculty member at the school and knew the graduates well; I wanted to inspire them.  

I remembered the story that inspires me the most—the story of Alex Scott. Like many others, I learned of Alex for the first time by watching the 2005 Kentucky Derby and hearing about her connection to Afleet Alex, the champion racehorse.  

I knew in my heart that this story would be the perfect centerpiece of the commencement address. After my speech and the graduation, many people asked if I had ever hosted a lemonade stand and sadly, the answer was no.  

I realized it was time to “walk the walk” and not just “talk the talk.”

Last year, with the encouragement and assistance of some great co-workers at my law firm, Lightfoot, Franklin & White, I decided to get off the sidelines and host my own stand. 

Our first lemonade stand was great fun and a big success. We raised about $12,500, crushing our goal of $2,000. We were featured on two local news stations and received much support from the community. For this year’s stand, we hope to raise $20,000 – an ambitious goal, but one we know we can reach.

To anyone out there who is considering hosting a lemonade stand, my advice is to just do it. And while I am by no means an expert, here a few tips for first-timers: 

  1. The story of Alex sells itself. Most people want to donate when they hear the story, especially if they also hear the story of Afleet Alex (if you don’t know the story of the horse, grab a tissue and watch the first video). Distribute flyers with the story, so no one can forget when and where to show up for your stand.
  2. Think of your stand as a campaign, as opposed to a one-time event. The actual lemonade stand should be the cherry on top and almost a celebration. Do the bulk of the fundraising ahead of time.
  3. Get others to buy in. For example, a local business, Milo’s Tea Company, donated our lemonade, and we put them on our ads. Find a business in your community and cut the same deal.
  4. Don’t just rely on mass advertising. Use the personal touch. People will often ignore blast emails or social media posts, but they are less likely to ignore a personal email, call, or a visit asking for a donation. And if they hear the story, they will want to donate.
  5. Use social media, but don’t rely solely on social media posts (see #4).
  6. Remember, it is not about you. This is for a cause greater than ourselves.

The best part of the day is spreading the word about a great cause. We will host our 2nd Annual Lightfoot Lemons Stand on June 7. 

Terry McCarthy is a lawyer at the law firm of Lightfoot, Franklin & White. Read more about his All Star Stand here.  Ready to get involved? You, too, can be a Lemonade Days stand host! Get the details here. ​












Lemonade Days