THE FIRST FEW weeks after diagnosis are utterly overwhelming. In the midst of confusion, fear, and fatigue, you might need to make an important and sometimes difficult decision: whether to choose the best-known treatment (standard treatment) or enroll your child in an experimental treatment (clinical trial). This chapter explains helpful things to know before deciding on a treatment for your child, including the difference between standard treatment and clinical trials. It also covers questions to ask about proposed treatments, informed consent, the pros and cons of selecting a clinical trial, and stories from parents about the decisions they made.