Childhood Cancer

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Predisposition

While most cases of childhood cancer are sporadic events, approximately 10% of children and adolescents diagnosed with cancer have an underlying genetic mutation that predisposes them to cancer. Cancer predisposition syndromes, such as RUNX1 Familial Platelet Disorder, Li-Fraumeni Syndrome, and Beckwith-Wiedemann Syndrome, lead to an increased risk of one or more cancers over the lifetime of the individual. A better understanding of disease biology, along with genetic testing, genetic counseling and cancer surveillance may result in improved outcomes for children with cancer predisposition syndromes.

Latest Predisposition grants

Lucio Castilla, PhD, Principal Investigator
University of Massachusetts Medical School
Familial RUNX1 Research Grants, Awarded 2020
Zuzana Tothova, MD/PhD, Principal Investigator
Broad Institute
RUNX1 Early Career Investigator Grants, Awarded 2019
Jennifer Kalish, MD/PhD, Principal Investigator
Children's Hospital of Philadelphia
Epidemiology Grants, Awarded 2019

Predisposition Heroes