Childhood Cancer

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Anti-Angiogenic Effects of BAI Proteins in Neuroblastoma

Children’s Hospital of Philadelphia
Naomi Balamuth, MD
Grant Type: 
Young Investigator Grants
Year Awarded: 
Type of Childhood Cancer: 
Project Description: 

The three specific aims of this project are to:
•    Develop a tractable in vivo model for the monitoring of dynamic changes in neuroblastoma vascularization during tumor growth and in the context of chronic VEGF inhibition.
•    Define optimal targets for synergistically enhancing the tumor growth delay mediated by anti-angiogenic effects of VEGF inhibition.
•    Perform preclinical trials to define optimal dual angiogenesis inhibition strategies that are readily translatable to the clinic.