Where the Money Goes

You are here

Anti-Angiogenic Effects of BAI Proteins in Neuroblastoma

Institution: 
Children's Hospital of Philadelphia
Researcher(s): 
Naomi Balamuth, MD
Grant Type: 
Young Investigator Grants
Year Awarded: 
2006
Type of Childhood Cancer: 
Neuroblastoma
Project Description: 

The three specific aims of this project are to:
•    Develop a tractable in vivo model for the monitoring of dynamic changes in neuroblastoma vascularization during tumor growth and in the context of chronic VEGF inhibition.
•    Define optimal targets for synergistically enhancing the tumor growth delay mediated by anti-angiogenic effects of VEGF inhibition.
•    Perform preclinical trials to define optimal dual angiogenesis inhibition strategies that are readily translatable to the clinic.