ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
Project Title |
Institution / Principal Investigator(s) | Grant Type | Year | State |
|---|---|---|---|---|
| Vaccine-boosted CAR T cell therapy for high risk neuroblastoma | Children’s Hospital of Philadelphia / Timothy Spear, MD/PhD | Young Investigator Grants | 2024 | Pennsylvania |
| Utilizing chromatin directed inhibitors to regulate gene expression in Ewing sarcoma for therapeutic benefit | University of North Carolina / Justin Sperlazza, MD/PhD | Young Investigator Grants | 2024 | North Carolina |
| Unraveling the Mechanisms of Inherited Predisposition to Childhood Leukemia | Boston Children’s Hospital / Vijay Sankaran, MD/PhD | Innovation Grants | 2024 | Massachusetts |
| Unraveling GABAergic interneuron-like lineage in H3G34-mutant hemispheric high-grade gliomas: their impact on network formation and invasion | Dana-Farber Cancer Institute / Gustavo Alencastro Veiga Cruzeiro, PhD | Young Investigator Grants | 2024 | Massachusetts |
| Understanding the role of CDK8 in protein synthesis for treating MYC-driven medulloblastoma | University of Colorado Denver / Dong Wang, PhD | Young Investigator Grants | 2024 | Colorado |
| Uncovering new approaches to target FOXR2 in pediatric cancers | Children’s Hospital Los Angeles / Jessica Tsai, MD/PhD | 'A' Award Grants | 2024 | California |
| Translating sarcoma antigen-directed co-stimulatory NK cells to the clinic | Baylor College of Medicine / Robin Parihar | Reach Grants | 2024 | Texas |
| Translating sarcoma antigen-directed co-stimulatory NK cells to the clinic | Baylor College of Medicine / Robin Parihar, MD/PhD | Reach Grants | 2024 | Texas |
| Therapeutic targeting of clonal hematopoiesis in RUNX1 mutant FPDMM | University of Pennsylvania / Robert Bowman, Ph.D. | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2024 | Pennsylvania |
| The role of tissue kallikrein 1 in hematopoietic stem cell transplant-associated thrombotic microangiopathy | Baylor College of Medicine / Sarah Sartain, MD | Innovation Grants | 2024 | Texas |
| The role of reactive gliosis in response to Immunotherapy in Diffuse Midline Glioma | University of Florida / Christina von Roemeling, PhD | Innovation Grants | 2024 | Florida |
| The influence of the raphe nucleus and serotonin on progression of diffuse intrinsic pontine glioma | Stanford University / Richard Drexler, MD/PhD | Young Investigator Grants | 2024 | California |
| Targeting the immunosuppressive effects of Myc-hyperactivation in high-risk osteosarcoma | Emory University / Jason Yustein, MD/PhD | Innovation Grants | 2024 | Georgia |
| Targeting protein synthesis in pediatric acute myeloid leukemia | Cincinnati Children's Hospital Medical Center / Courtney Jones, PhD | 'A' Award Grants | 2024 | Ohio |
| Targeting of a putative unresolved wound healing process in childhood ependymoma | University of Colorado Denver / Nicholas Foreman, MD | Innovation Grants | 2024 | Colorado |
| Targeting Novel Inflammatory Signaling Pathways in Juvenile Myelomonocytic Leukemia | Indiana University / Santhosh Kumar Pasupuleti, PhD | 'A' Award Grants | 2024 | Indiana |
| Targeting and imaging immunometabolic vulnerabilities in diffuse midline glioma | The Regents of the University of California San Francisco / Pavithra Viswanath, PhD | Innovation Grants | 2024 | California |
| Systematic screening of receptor pairs combinations for improving solid tumor cancer immunotherapy | Texas Children’s Cancer Center / Xavier Rios, MD/PhD | 'A' Award Grants | 2024 | Texas |
| RAF Dimer Inhibitor Treatment in Pediatric Acute Myeloid Leukemia | The Regents of the University of California San Francisco / Kevin Shannon, MD | Innovation Grants | 2024 | California |
| Pathological Condensates and Transcription Dysregulation in Rhabdomyosarcoma at Single-Molecule Resolution | California Institute of Technology / Shasha Chong, PhD | Innovation Grants | 2024 | California |
| Overcoming Menin-inhibitor resistance | Children’s Hospital of Philadelphia / Kathrin Bernt, MD | Reach Grants | 2024 | Pennsylvania |
| Novel mechanisms and therapeutic targeting of chemoresistant rhabdomyosarcoma | Massachusetts General Hospital / Yueyang Wang, PhD | Young Investigator Grants | 2024 | Massachusetts |
| MYCN-induced molecular clock disruption and metabolic rewiring drive neuroblastoma | Baylor College of Medicine / Lingzhi Li, PhD | Young Investigator Grants | 2024 | Texas |
| Modifying CAR T cell epigenetic programs to improve therapy against aggressive pediatric brain tumors | St. Jude Children’s Research Hospital / Meghan Ward, PhD | Young Investigator Grants | 2024 | Tennessee |
| Investigating the impact of osteosarcoma genetic lesions on bone differentiation | Dana-Farber Cancer Institute / James Morrow, MD/PhD | Young Investigator Grants | 2024 | Massachusetts |
| In vivo transdermal generation of CD33 CAR T-cells towards acute myeloid leukemia | University of California, Los Angeles / Ruby Sims, PhD | Young Investigator Grants | 2024 | California |
| Improving homing and activity of CAR T cells in pediatric sarcomas | University of Colorado Denver / Joselyn Cruz Cruz, PhD | Young Investigator Grants | 2024 | Colorado |
| Illuminating Choroid Plexus Carcinoma Vascularization in Real Time | Boston Children’s Hospital / Maria Lehtinen, PhD | Innovation Grants | 2024 | Massachusetts |
| IGFBPL1 Peptide-Centric Chimeric Antigen Receptor Autologous T Cells for Relapsed HLA-A*02 Neuroblastoma and Medulloblastoma | Children’s Hospital of Philadelphia / John Maris, MD | Reach Grants | 2024 | Pennsylvania |
| Gene-mediated cytotoxic immunotherapy in pediatric patients with recurrent malignant brain tumors | University of Michigan / Andrea Franson, MD | 'A' Award Grants | 2024 | Michigan |
| Exploring the Interplay of Microbiome, Bile Acids, Immune Reconstitution, and Clinical Outcomes Following Allogeneic Hematopoietic Transplantation in Pediatrics | Memorial Sloan-Kettering Cancer Center / Oriana Miltiadous, MD | Reach Grants | 2024 | New York |
| Exploiting a Novel DNA Repair Defect in Ewing Sarcoma | Dana-Farber Cancer Institute / Shuhei Asada, MD/PhD | Young Investigator Grants | 2024 | Massachusetts |
| DMG: From SWI/SNF’s role in cholesterol biosynthesis to new therapeutic opportunities | Board of Trustees of the Leland Stanford Junior University / Capucine Van Rechem, PhD | Innovation Grants | 2024 | California |
| Direct targeting of oncoprotein assembly using mimetic peptide interference | Memorial Sloan-Kettering Cancer Center / Alex Kentsis, MD/PhD | Innovation Grants | 2024 | New York |
| Development of CAR-T therapy for Ewing sarcoma using zebrafish in vivo models | Children’s Hospital Los Angeles / James Amatruda, MD/PhD | Innovation Grants | 2024 | California |
| Development of CAR-T therapy for Ewing sarcoma using zebrafish in vivo models | Children’s Hospital Los Angeles / James Amatruda, MD/PhD | Innovation Grants | 2024 | California |
| Development of allogeneic off-the-shelf gamma delta T cell product for pediatric AML | Baylor College of Medicine / Norihiro Watanabe, PhD | Innovation Grants | 2024 | Texas |
| Defining how unique properties of the pediatric immune system contribute to poor efficacy of checkpoint blockade in children | Stanford University / Adrienne Long, MD/PhD | Young Investigator Grants | 2024 | California |
| Collective cell invasion of fusion positive rhabdomyosarcoma regulated by PAX3-FOXO1 | Children’s Hospital Los Angeles / Jinseok Park, PhD | 'A' Award Grants | 2024 | California |
| Capitalizing on functional genomics with targeted protein degradation in neuroblastoma | St. Jude Children’s Research Hospital / Ian Delahunty, PhD | Young Investigator Grants | 2024 | Tennessee |