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Protein identified that drives initiation and growth of aggressive form of leukemia

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Eureka Alert


A team led by Massachusetts General Hospital (MGH) investigators has identified a new cancer-causing pathway behind most cases of an aggressive type of leukemia, findings that could lead to new targeted treatment approaches. In the report published online in Cancer Discovery, the team describes finding a protein called TOX (thymocyte selection-associated high mobility box protein) that acts in concert with other oncogenes to initiate the development of T-cell acute lymphoblastic leukemia (T-ALL).

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