Childhood Cancer

You are here

Development of Nanoparticle-Encapsulated Chemo/Radio-Sensitizers for Intrathecal Delivery

Institution: 
Yale School of Medicine
Researcher(s): 
Ranjit S. Bindra, MD/PhD & Mark Saltzman, PhD
Grant Type: 
Innovation Grants
Year Awarded: 
2017
Type of Childhood Cancer: 
Brain Tumors
Project Description: 

Background 
Pediatric brain tumors often are treated with high doses of chemotherapy and radiation therapy. These treatments are effective but lead to significant late effects on long-term survivors. 

Project Goal 
We seek to develop a new approach to deliver radio- and chemo-sensitizing agents directly into the spinal cord fluid, where tumor cells often are found and mediate recurrence. This approach will greatly enhance treatment responses, while at the same time minimizing toxicity.

Co-funded by: 
Tap Cancer Out