Development of Nanoparticle-Encapsulated Chemo/Radio-Sensitizers for Intrathecal Delivery
Pediatric brain tumors often are treated with high doses of chemotherapy and radiation therapy. These treatments are effective but lead to significant late effects on long-term survivors.
We seek to develop a new approach to deliver radio- and chemo-sensitizing agents directly into the spinal cord fluid, where tumor cells often are found and mediate recurrence. This approach will greatly enhance treatment responses, while at the same time minimizing toxicity.