Childhood Cancer

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Norepinephrine Transporter-Targeted Pharmacotherapy of Aggressive Neuroblastoma

Institution: 
Children's Hospital of Philadelphia
Researcher(s): 
Michael Chorny, PhD, Garrett M. Brodeur, PhD & Ivan S. Alferiev, PhD
Grant Type: 
Innovation Grants
Year Awarded: 
2019
Type of Childhood Cancer: 
Neuroblastoma
Project Description: 

Neuroblastoma remains the deadliest solid tumor of childhood. It is often diagnosed in the advanced stages where existing therapies fail to cure over half of the patients. New therapies effective at treating the aggressive form of the disease are therefore urgently needed.

Project Goal

The present studies focus on an experimental treatment with enhanced pharmacological selectivity using polymer-liked prodrugs to deliver a potent chemotherapeutic agent chemically functionalized for tumor cell targeting. If proven effective, this polymeric prodrug-based approach can provide a means to suppress aggressive tumors without causing major toxicity often seen with traditional chemotherapy.