Risk factors and outcomes in pediatric patients with therapy-related myelodysplastic syndrome and secondary acute myeloid leukemia
Mentor: Dr. Elliot Stieglitz
Therapy related myelodysplastic syndrome (tMDS) and secondary acute myeloid leukemia (sAML) are rare, but often fatal, complications of chemotherapy, with stem cell transplantation as the only known curative option. However, little is known about the risk factors for development of tMDS or sAML nor the optimal choice for treatment. During the past 20 years, we have identified 19 pediatric patients with tMDS or sAML at University of California San Francisco (UCSF). We plan on collecting and sequencing DNA from all of these patients using bone marrow slides from diagnosis and where applicable, remission. Corresponding clinical information describing treatments and outcomes will be collected from the electronic medical record and stored in an online database called REDCap. The goal of this project is to identify genetic risk factors for developing tMDS or sAML and to describe our single institutional experience regarding optimal treatment strategies for publication.