Targeting Microenvironmental Support of Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer and relapsed ALL is the most common cause of death from childhood cancer. Exciting new research has shown that leukemia cells depend their survival on nonmalignant, noncancerous cells in the body.
This research project explores the ways nonmalignant cells help leukemia cells. Discoveries from this research project have identified specific ways that nonmalignant cells can be treated with drugs in ways that interfere with them keeping leukemia cells alive. This project will study ways these treatments can be combined with current chemotherapy to make them more effective against leukemia.