The Alex's Lemonade Stand Foundation's Crazy 8 Initiative funds collaborative, multidisciplinary research to solve the most challenging childhood cancer problems, aiming to find cures and improve treatments by supporting innovative, high-risk projects that traditional funding may not cover. The initiative fosters international partnerships between scientists to accelerate discoveries from the lab to clinical trials. The initiative targets critical barriers of complex childhood cancer like resistance to treatments, identifying and preventing cancers in children with genetic predispositions and treating previously untreatable cancer by addressing complex genetic changes that cause or promote the growth and spread of cancer in kids.