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Young Investigator Grants

Young Investigator grants are designed to fill the critical need for startup funds for less experienced researchers to pursue promising research ideas. Eligible applicants may apply during their fellowship training or early in their research careers but must not have achieved an appointment higher than Instructor. These grants encourage and cultivate the best and brightest researchers of the future and lead to long-term research projects. The Young Investigator grant offers up to $60,000 per year for three years.

Download the 2026 Young Investigator Grant Application Guidelines

All Early Career Research Programs All ALSF Funded Projects
2025
Next-Generation CAR-T Cell Immunotherapies for Pediatric Acute Myeloid Leukemia
Gabriele Casirati, PhD
Boston Children’s Hospital
2025
The role of senescence in diffuse midline glioma tumorigenesis and treatment resistance
Timothy Chang, MD/PhD
Dana-Farber Cancer Institute
2025
Elucidating and Targeting the Cell Surface Proteome of Pediatric T Cell Acute Lymphoblastic Leukemia
Mark Gower, PhD
University Health Network
2025
Enhancing GPC2 CAR T-cell therapy against retinoblastoma
Grant Grothusen, PhD
Children’s Hospital of Philadelphia
2025
Vaccine-Boosted Tumor Microenvironment-Restricted Multi-Antigen Targeting CAR T for Pediatric High-Grade Gliomas
Tomasz Grzywa, MD/PhD
Children’s Hospital of Philadelphia
2025
Hyperactivating oncogenic ETS factors to selectively target CIC-rearranged sarcomas
Peter Hendrickson, MD/PhD
Duke University
2025
Elucidating the tumor promoting roles of itaconate in ZFTA-RELA Fusion driven ependymomas
Siva Kumar Natarajan, PhD
University of Michigan
2025
Elucidating the role of MIF in the immunosuppressive tumor microenvironment of Ewing sarcoma
Christopher Kuo, MD
Children’s Hospital Los Angeles
2025
Targeting Chromatin-Remodeling Complexes in ZNF384-rearranged Mixed Phenotype Acute Leukemia.
Clara Libbrecht, MD/PhD
Seattle Children’s Hospital
2025
Targeting H3K27M Pediatric Diffuse Midline Gliomas Through Induced Viral Mimicry
Angela Liou, MD
Sanford-Burnham Medical Research Institute
2025
Wearable Sensors for Fever Detection in Children with Cancer in Kenya: An Implementation Science Study
Nate Nessle, DO
University of Michigan
2025
Uncovering Oncogenic Mechanisms in T-ALL Through Multi-Omics and Advanced Genomic Profiling
Petri Pölönen, PhD
St. Jude Children’s Research Hospital
2025
Investigation of SMARCAL1 as a targetable dependency in BRAF-mutant gliomas
Jenna Robinson, PhD
Dana-Farber Cancer Institute
2025
Epigenetic reprogramming of drug-resistant cell states in high-risk neuroblastoma for therapeutic benefit
Noha Shendy, PhD
St. Jude Children’s Research Hospital
2025
A biophysical approach to improve CAR T cell efficacy against diffuse midline gliomas
Sauradeep Sinha, PhD
St. Jude Children’s Research Hospital
2025
Epigenetic Regulation of MYC in Pediatric Cancer: Investigating the Role of Ancestral Repetitive Elements and Nuclear Positioning
Daniel Solvie, PhD
Dana-Farber Cancer Institute
2025
Chimeric cytokine receptors to improve CAR T-cell therapy for osteosarcoma
Xirui Song, PhD
St. Jude Children’s Research Hospital
2025
Establishing Biomarkers of Stem Cell Fitness to Improve HSC Transplants for Pediatric Cancer Patients
Helena Yu, MD
University of California, San Diego
2025
Characterizing the role of measurable residual disease (MRD) in pediatric acute myeloid leukemia (AML) survival disparities
Daniel Zheng, MD
Children’s Hospital of Philadelphia
2025
Exploring the functions of SMARCD3-Reeling signaling in the metastasis phenotype and in the subgroups transition of medulloblastoma
Han Zou, MD/PhD
University of Pittsburgh
2024
Novel mechanisms and therapeutic targeting of chemoresistant rhabdomyosarcoma
Yueyang Wang, PhD
Massachusetts General Hospital
2024
Exploiting a Novel DNA Repair Defect in Ewing Sarcoma
Shuhei Asada, MD/PhD
Dana-Farber Cancer Institute
2024
Unraveling GABAergic interneuron-like lineage in H3G34-mutant hemispheric high-grade gliomas: their impact on network formation and invasion
Gustavo Alencastro Veiga Cruzeiro, PhD
Dana-Farber Cancer Institute
2024
Understanding the role of CDK8 in protein synthesis for treating MYC-driven medulloblastoma
Dong Wang, PhD
University of Colorado Denver
2024
Modifying CAR T cell epigenetic programs to improve therapy against aggressive pediatric brain tumors
Meghan Ward, PhD
St. Jude Children’s Research Hospital
2024
In vivo transdermal generation of CD33 CAR T-cells towards acute myeloid leukemia
Ruby Sims, PhD
University of California, Los Angeles
2024
Defining how unique properties of the pediatric immune system contribute to poor efficacy of checkpoint blockade in children
Adrienne Long, MD/PhD
Stanford University
2024
Capitalizing on functional genomics with targeted protein degradation in neuroblastoma
Ian Delahunty, PhD
St. Jude Children’s Research Hospital
2024
Vaccine-boosted CAR T cell therapy for high risk neuroblastoma
Timothy Spear, MD/PhD
Children’s Hospital of Philadelphia
2024
Improving homing and activity of CAR T cells in pediatric sarcomas
Joselyn Cruz Cruz, PhD
University of Colorado Denver
2024
MYCN-induced molecular clock disruption and metabolic rewiring drive neuroblastoma
Lingzhi Li, PhD
Baylor College of Medicine
2024
Utilizing chromatin directed inhibitors to regulate gene expression in Ewing sarcoma for therapeutic benefit
Justin Sperlazza, MD/PhD
University of North Carolina
2024
The influence of the raphe nucleus and serotonin on progression of diffuse intrinsic pontine glioma
Richard Drexler, MD/PhD
Stanford University
2024
Investigating the impact of osteosarcoma genetic lesions on bone differentiation
James Morrow, MD/PhD
Dana-Farber Cancer Institute
2023
Ex Vivo Modeling of Medulloblastoma using Human iPSC-Derived Cerebellar Organoids
Stephanie Wu, PhD
St. Jude Children’s Research Hospital
2023
Targeting Oncogenic N-MYC Complexes in High-Risk Neuroblastoma
Bo Qiu, MD/PhD
The Regents of the University of California San Francisco
2023
A Novel Adjunctive LAT-Activating CART (ALA-CART) Cell Platform for the Treatment of Acute Leukemia
Catherine Danis, PhD
University of Colorado Denver_ Anschutz Medical Campus
2023
Arginine Depletion with DFMO in High-Risk Neuroblastoma
Christina Turn, MD
Children’s Hospital of Philadelphia
2023
Elucidating the Roles of Aneuploidy in Down Syndrome-Associated Leukemia
Chun-Chin Chen, PhD
Boston Children’s Hospital
2023
Radiation and the Tumor Microenvironment in an Immunocompetent Model of Ewing Sarcoma
Jessica Daley, MD
Children’s Hospital of Pittsburgh Foundation
2023
Synthetic Gene Expression Regulatory Switches (SynGERS) for Improved CAR T Cell Function in Pediatric Solid Tumors
Leidy Diana Caraballo Galva, PhD
Baylor College of Medicine
2023
Identifying Therapeutic Vulnerabilities in Pediatric AML through Investigation of the MECOM Transcriptional Network
Richard Voit, MD/PhD
University of Texas Southwestern Medical Center
2023
CDK8 as a New Therapeutic Target in Alveolar Rhabdomyosarcoma
Susu Zhang, PhD
Dana-Farber Cancer Institute
2023
Mechanisms of BRAF Activation in KIAA1549-BRAF Mutant pLGGs
Sean Misek, PhD
Broad Institute
2023
Pre-Targeted Radioimmunotherapy for Desmoplastic Small Round Cell Tumors
Madelyn Espinosa-Cotton, PhD
Memorial Sloan-Kettering Cancer Center
2023
Identifying Ewing Sarcoma Developmental Vulnerabilities
Elena Vasileva, PhD
Children’s Hospital Los Angeles
2023
Targeting the Checkpoint Receptor TIGIT via CRISPR/Cas9 Genome Editing to Enhance NK Cell Anti-Tumor Activity
Amanda Campbell, MD/PhD
Research Institute at Nationwide Children's Hospital
2021
STING Pathway Activation: The Missing Link between Genomic Instability and Antitumor Immunity in Osteosarcoma
Elizabeth Young, MD
University of California San Francisco
2021
Activating Metabolic Pathways to Increase the Persistence of Leukemia Targeting T Cells
Erica Braverman, MD
Children’s Hospital of Pittsburgh
2021
Redefining Osteosarcoma Metastases as Chronic Non-healing Lung Wounds: Implications for Developing Novel Therapies
James Reinecke, MD/PhD
Research Institute at Nationwide Children's Hospital
2021
Social Determinants of Health, Hospital-level Resources, and Risk of Septic Shock in Pediatric Leukemia
Jenny Ruiz, MD
Children’s Hospital of Philadelphia
2021
Dissecting Functional uORFs as a Source of Cancer Genes in High-Risk Medulloblastoma
John Prensner, MD/PhD
Dana-Farber Cancer Institute
2021
Dissecting the Contribution and Inheritance of Germline DNA Damage Repair Gene Mutations in Neuroblastoma
Riaz Gillani, MD
Dana-Farber Cancer Institute
2021
Exploiting the Potential of Bromodomain Inhibitors in Ewing Sarcoma
Shireen Ganapathi, MD
Seattle Children’s Hospital
2021
The Role of LIN28B-let-7-PBK Axis on the Growth and Metastasis of Group 3 Medulloblastoma
Shubin Shahab, MD/PhD
Emory University
2021
Function and Dependency of NFkB Activity in ZFTA-RELA Fusion Ependymoma
Austin Stuckert, MD
Baylor College of Medicine
2021
Neural Crest Gene Regulatory Networks Underlying Normal Meningeal Development and Onset of Meningioma
Ayyappa Raja Desingu Rajan, PhD
California Institute of Technology
2021
Investigating Epigenetic Mechanisms of Response to Allogenic CAR T Cell Therapy
Caitlin Zebley, MD/PhD
St. Jude Children’s Research Hospital
2021
Hematopoietic Stem And Progenitor Cells Sustain Inflammation And Promote Relapse In The AML Niche
Ding-Wen (Roger) Chen, PhD
Children’s Hospital of Philadelphia
2020
Targeting the Rac GTPase Pathway to Sabotage RAS Signaling in RAS-mutated Leukemia
Sara Canovas Nunes, PhD
Boston Children’s Hospital
2020
GPC2 CAR T Cell Targeted Delivery of BiKEs in High-Risk Neuroblastoma
Guillem Pascual-Pasto, PhD
Children’s Hospital of Philadelphia
2020
Modeling the Initiation and Progression of Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution
Elvin Wagenblast, PhD
Icahn School of Medicine at Mount Sinai
2020
Identifying Epistatic Suppressors of Oncohistone in Pediatric High-Grade Gliomas
Carol Chen, PhD
BC Cancer (Provincial Health Services Authority)
2020
Novel Synergistic Targets for Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
Yang Ding, MD
Children’s Hospital of Philadelphia
2020
Donor T-Cell DNA Methylation in GVHD and the Graft-vs-Tumor Effect after Allogeneic Hematopoietic Stem Cell Transplant
Yiouli Panayiota Ktena, MD
The Johns Hopkins University School of Medicine
2020
High-throughput CAR NKT Library Screen for Improving Neuroblastoma Immunotherapy
Xavier Rios, MD/PhD
Baylor College of Medicine
2020
Using Neurofibromatosis-1 (NF1) to understand Pediatric Brain Tumor Initiation
Yuan Pan, PhD
MD Anderson Cancer Center
2020
Dissecting the Role of FOXR2 in the Oncogenesis of Diffuse Intrinsic Pontine Glioma
Jessica Tsai, MD/PhD
Dana-Farber Cancer Institute
2019
Therapeutic Targets and Molecular Mechanisms in Childhood Brainstem Tumors
Jerome Fortin, PhD
University Health Network - Toronto Western Research Institute
2019
Bcl2-Family Inhibitors in Neuroblastoma: Mechanism of Action, Therapy Resistance, and Development of Biomarkers
Claudia Zapata, MD
Children’s Hospital of Philadelphia
2019
Defining the Molecular Mechanisms Underlying Pediatric Brain Tumor Penetrance
Nicole Brossier, MD/PhD
Washington University
2019
Investigation of Pediatric Rhabdomyosarcoma Recurrence through Single-Cell Sequencing
Anand Patel, MD/PhD
St. Jude Children’s Research Hospital
2019
The Role of Tumor Heterogeneity in Relapse of Pediatric Acute Myeloid Leukemia
Cheryl Peretz, MD
Children’s Hospital & Research Center at Oakland
2019
MLL Oncogene-Dependent Enhancer Reprogramming Promotes Leukemogenesis
Feng Pan, PhD
Stanford University
2019
Kidney Disease after CD19-Targeted Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia
Regina Myers, MD
Children’s Hospital of Philadelphia
2019
Modeling H3 G34R and BCOR-Altered Glioma Pathogenesis Using Neural Stem Cells
Satoshi Nakata, MD/PhD
The Johns Hopkins University School of Medicine
2019
Characterization of Chromatin Landscapes to Identify Therapeutic Vulnerabilities in Diffuse Midline Gliomas.
Jay Sarthy, MD/PhD
Fred Hutchinson Cancer Research Center
2019
Enhancing the therapeutic efficacy of chimeric antigen receptor T cells for acute myeloid leukemia
Miriam Kim, MD
Washington University
2019
Targeting Valine-Specific Amino Acid Dependency -in T-Cell Acute Lymphoblastic Leukemia
Palaniraja Thandapani, PhD
New York University School of Medicine
2019
The Impact Of CD56neg NK Cells in the Pathogenesis of Endemic Burkitt Lymphoma
Catherine Forconi, PhD
University of Massachusetts Medical School
2019
Identification of Synthetically Immunogenic Compounds to Synergize with Immunotherapy in Neuroblastoma
Adam Wolpaw, MD/PhD
Children’s Hospital of Philadelphia
2019
Improving CAR T-Cell Therapy for Pediatric Osteosarcoma by Manipulating Arginine Metabolism
Shannon Lange, PhD
St. Jude Children’s Research Hospital
2019
Targeting TGFb Pathway Dependencies in Group 3 Medulloblastoma
Zulekha Qadeer, PhD
University of California San Francisco
2019
Targeted Hyperactivation of PI3K/AKT in B-cell malignancies
Vishal Khairnar, PhD
Dana-Farber Cancer Institute
2019
ECM-targeted CAR T-cell therapy for high-grade glioma
Jessica Wagner, PhD
St. Jude Children’s Research Hospital
2019
The Role of Germline Variants in Infant Leukemogenesis
Margaret Ferris, MD/PhD
Washington University
2019
Novel Genomic Drivers in Pediatric Polyposis Syndromes
Suzanne MacFarland, MD
Children’s Hospital of Philadelphia
2018
Interrogation of Neuroblastoma Dependencies and RNAs on the Core-Regulatory Circuitry for Therapeutic Inhibition
Adam Durbin, PhD
St. Jude Children’s Research Hospital
2018
Pedi-PRESTO: Pediatric Patient-Reported Symptom Tracking in Oncology
Allison Barz Leahy, MD
Children’s Hospital of Philadelphia
2018
Beyond Febrile Neutropenia: Risks Associated with Antibiotic Choice in Children with Leukemia that Undergo Transplant
Caitlin Elgarten, MD
Children’s Hospital of Philadelphia
2018
Cooperating Signaling Networks Regulate Cell Survival of Pediatric Ph-like ALL
Christian Hurtz, PhD
University of Pennsylvania
2018
Accessing Combinatorial Effect of PARP Inhibitor with DNA Damaging Agent in Rhabdomyosarcoma at Single Cell Resolution
Chuan Yan, PhD
Massachusetts General Hospital
2018
Novel Antibodies to the C2-set Domain of CD33 for Acute Myeloid Leukemia Immunotherapy
Colin Godwin, MD
Fred Hutchinson Cancer Research Center
2018
Describing the Biological Impacts of Gain-of-function SAMD9 Mutations
Jason Schwartz, MD/PhD
Vanderbilt University Medical Center
2018
MYC-driven Core Regulatory Circuits in Neuroblastoma
Mark Zimmerman, PhD
Dana-Farber Cancer Institute
2018
Divergent Core Transcriptional Regulatory Circuitries to Highlight Context-Specific Vulnerabilities in AML
Maxim Pimkin, MD/PhD
Dana-Farber Cancer Institute
2018
Augmenting Chimeric Antigen Receptor T Cell Induced Epitope Spreading for Pediatric Solid Tumors
Michael Leibowitz, MD/PhD
Children’s Hospital of Philadelphia
2018
Targeting the Metabolic Drivers of Chemo Resistance in Acute Myeloid Leukemia
Nick van Gastel, PhD
Harvard University
2018
Effect of SLCO Polymorphisms on High-Dose Methotrexate Clearance in Pediatric Oncology Patients
Rachael Schulte, MD
Vanderbilt University Medical Center
2018
Investigating the role of BAI1 in the Metastasis of Medulloblastoma
Satoru Osuka, MD/PhD
University of Alabama at Birmingham
2018
Modeling GATA2 Associated MDS/AML Predisposition Syndrome Using Color-Barcoding and Mutagenesis in Zebrafish
Serine Avagyan, PhD
Dana-Farber Cancer Institute
2018
NUDT15 Polymorphisms and Individualization of Thiopurine Therapy in Children with Acute Lymphoblastic Leukemia
Takaya Moriyama, MD/PhD
St. Jude Children’s Research Hospital
2018
Therapeutic Targeting of Childhood Leukemia by Pharmacological Inhibition of Proteolytic Cleavage of MLL1
Zibo Zhao, PhD
Northwestern University (Illinois)
2017
Development of Novel Biomarkers for Immunotherapy in Neuroblastoma
Shuobo Boboila, PhD
Columbia Institute for Cancer Genetics
2017
Identifying Disease Mechanisms and Therapeutic Opportunities in Pediatric Low-grade Gliomas Driven by MYB-QKI Fusions
Cecile Rouleau, PhD
Dana-Farber Cancer Institute
2017
Cancer Susceptibility and Signaling Pathways in Low-Grade Brain Tumors
Bárbara Rivera, PhD
Jewish General Hospital
2017
Elucidating the Role of N-Myc in a High-risk Pediatric T Cell Leukemia
Francesco Boccalatte, PhD
New York University School of Medicine
2017
Identification and Characterization of Pathways Dysregulated by MMSET E1099K Mutation in Relapsed Pediatric Acute Lymphoblastic Leukemia and Their Role in Drug Resistance
Joanna Pierro, DO
New York University School of Medicine
2017
Identification and Targeting of Microenvironmental Factors Controlling Pediatric Leukemia
Anastasia Tikhonova, PhD
New York University School of Medicine
2017
End-of-Life Care of Children with Cancer: Variation and Stakeholder Priorities
Emily Johnston, MD
University of Alabama at Birmingham
2017
Preclinical Efficacy of Daratumumab in T Cell Acute Lymphoblastic Leukemia
Karen Bride, MD/PhD
New York University School of Medicine
2017
Targeting Protein Translation to Antagonize MYC-driven Neuroblastoma
Andrea Franson, MD
Children’s Hospital of Philadelphia
2017
Epigenomic Mechanisms of Neuroblastoma Tumorigenesis
Jo Lynne Harenza, PhD
Children’s Hospital of Philadelphia
2017
Anthracycline-Induced Cardiac Toxicity in Pediatric Acute Myeloid Leukemia
Kelly Getz, PhD
University of Pennsylvania
2017
Targeting Glutamine Metabolism in MYC Driven Atypical Teratoid Rhabdoid Tumors
Jeffrey Rubens, MD
The Johns Hopkins University School of Medicine
2017
High-Throughput Gene-Editing via Microfluidic Cell Deformability to Enable Off-the-Shelf Allogeneic Cellular Immunotherapies
Steven Jonas, MD/PhD
University of California, Los Angeles
2017
Overcoming Glucocorticoid Resistance in Lymphoid Cancers
Anica Wandler, PhD
University of California San Francisco
2017
The Impact of Hypoxia on Epigenetic Changes in Neuroblastoma
Sakshi Uppal, PhD
University of Chicago
2017
Development and Characterization of Novel Models of Human Osteosarcoma Development and Metastasis
Beau Webber, PhD
University of Minnesota
2017
Role of N6-Methyladenosine (m6A) mRNA Modification Pathway in Neuroblastoma
Shuibin Lin, PhD
Boston Children’s Hospital
2017
Understanding the Mechanisms of HOX Gene Regulation in Normal and Leukemic Hematopoietic Stem Cells to Identify New Therapies for Pediatric AML
Anne Robertson, PhD
Boston Children’s Hospital
2016
Targeting Metabolism as a Therapeutic Approach for High-Risk MYCN-Driven Neuroblastoma
Nicole Anderson, PhD
University of Pennsylvania
2016
CD19 Delta Ex2 Isoform as a Target for Alternative Therapies in Relapsed Pediatric B-ALL
Asen Bagashev, PhD
Children’s Hospital of Philadelphia
2016
Micro-environmental Regulators of Ewing sarcoma Metastasis
Kelly Bailey, MD/PhD
University of Pittsburgh
2016
Developing Targeted Immunotherapy Against Pediatric Acute Myeloid Leukemia
Melinda Biernacki, MD
Fred Hutchinson Cancer Research Center
2016
GPC2 as an Oncogene and Immunotherapeutic Target in High-risk Neuroblastoma
Kristopher Bosse, MD
Children’s Hospital of Philadelphia
2016
The Role of MiRNA Impairment in Wilms' Tumor Formation
Kenneth Chen, MD
University of Texas Southwestern Medical Center at Dallas
2016
Molecular Basis of ALK Inhibition Resistance in High-risk Neuroblastoma
David Debruyne, PhD
Dana-Farber Cancer Institute
2016
Variation in Care and Outcomes in Pediatric Acute Leukemia - Amanda DiNofia, MD (2016)
Amanda DiNofia, MD
Children’s Hospital of Philadelphia
2016
A Role for Non-canonical Wnt/PCP Signaling in Growth and Self-Renewal of Embryonal Rhabdomyosarcoma
Madeline Hayes, PhD
Massachusetts General Hospital
2016
Genetically Engineered T Cells as Therapy for Pediatric Glioma
Giedre Krenciute, PhD
Baylor College of Medicine
2016
Single-cell RNA-seq Profiling of Transcriptional Transition States During Human Retinoblastoma
Sunhye Lee, PhD
Children’s Hospital Los Angeles
2016
Interrogating the Enhancer Landscapes of Ependymoma to Inform Novel Therapies
Stephen Mack, PhD
Baylor College of Medicine
2016
Pre-clinical Evaluation of LSD1 Inhibitors for the Treatment of Pediatric Ewing sarcoma: Defining the Biomarkers of Sensitivity and Mechanisms of Resistance
Kathleen Pishas, PhD
Research Institute at Nationwide Children's Hospital
2016
Elucidating the Role of Human FAN1 Nuclease in DNA Crosslink Repair
Timsi Rao, PhD
Yale School of Medicine
2016
Role of Kindlin-3 In Natural Killer Cell Mediated Tumor Killing
Nathan Schloemer, MD
Children’s Hospital of Wisconsin - Milwaukee
2016
The Role of ARID1A in Neuroblastoma Pathogenesis
Hui Shi, PhD
Dana-Farber Cancer Institute
2016
Bad Influence: EWS/FLI Alters LSD1 and NuRD Interactions to Enforce Oncogenic Function in Ewing’s
Emily Theisen, PhD
Research Institute at Nationwide Children's Hospital
2016
Resistance and Develop Improved Treatments for Relapsed/refractory Pediatric ALL
Elizabeth Townsend, PhD
Dana-Farber Cancer Institute
2016
A CRISPRi Genetic Screen in Ewing sarcoma Identifies a Novel Dependence on Homologous Recombination DNA Repair
Asmin Tulpule, MD/PhD
University of California San Francisco
2016
Targeting Eya2 to Inhibit c-Myc driven Medulloblastoma Tumor Progression - Melanie Vincent, PhD (2016)
Melanie Vincent, PhD
University of Colorado Denver
2016
Investigating Racial Disparities in Pediatric Acute Leukemia
Lena Winestone, MD
University of California San Francisco
2016
Identification of Mechanisms of Resistance to Trametinib Monotherapy in PAX-fusion Negative Rhabdomyosarcoma
Marielle Yohe, MD/PhD
National Cancer Institute
2015
Functional Dissection of Oncogenic Enhancers in T-ALL
Daniel Herranz, PhD
Columbia University
2015
Elucidating Mechanisms Driving Renal Medullary Carcinomas to Deliver a Rational Approach to Cancer Directed Therapy
Andrew Hong, MD
Dana-Farber Cancer Institute
2015
Zebrafish Modeling of PAX3-FOXO1 Driven Rhabdomyosarcoma
Genevieve Kendall, PhD
University of Texas Southwestern Medical Center
2015
Enhancing the Viability, Function, and Safety, of Genetically-Enhanced NK Cells Within the Solid Tumor Microenvironment With IL-15 and a Suicide Gene
Robin Parihar, MD/PhD
Baylor College of Medicine
2015
Targeting Secondary Mutations in Juvenile Myelomonocytic Leukemia
Elliot Stieglitz, MD
University of California San Francisco
2015
CAMKV as a Target for Immunotherapy in MYCN-Amplified Neuroblastoma
Robyn Sussman, PhD
Children’s Hospital of Philadelphia
2015
The Role of DEF and SSU Processome in Neuroblastoma Pathogenesis
Ting Tao, PhD
Dana-Farber Cancer Institute
2015
Novel Nanoscale Phosphoproteomic Discovery of Therapeutic Targets in AML Stem Cells
Leo Wang, MD/PhD
Dana-Farber Cancer Institute
2015
Understanding the Role of Translational Control in Humanized Mouse Models for Medulloblastoma
Ozlem Aksoy, PhD
University of California San Francisco
2015
Chemical Genetics and CRISPRi/a Screen for Novel Therapeutic Targets in a Humanized Model for MYCN Associated High-Risk Pediatric Neuroblastoma
Zhenyi An, PhD
University of California San Francisco
2015
Elucidating the Mechanism of ERK Mediated Pathogenesis of LCH
Rikhia Chakraborty, PhD
Baylor College of Medicine
2015
The Cebpa Downstream Enhancer as a Key Target of Transformation to Acute Myeloid Leukemia
Stacy Cooper, MD
The Johns Hopkins University School of Medicine
2015
The Role of PARP3 in the Formation of Chromosomal Translocations
Tovah Day, PhD
Dana-Farber Cancer Institute
2015
Regulation of Hematopoietic Stem Cell Engraftment by the Endothelial Cell Niche
Bradley Blaser, MD/PhD
Boston Children’s Hospital
2015
Engager T Cells: A Novel Immunotherapeutic for AML
Challice Bonifant, MD/PhD
University of Michigan
2015
The YB1 Way of Surviving Radiation, Pediatric Brain Tumor Resistance and Recurrence
Abhinav Dey, PhD
Emory University
2015
Genetic Dissection of Cancer Drug Resistance and Toxicity Using Haploid Human Cells
Ramin Dubey, PhD
Stanford University
2015
Novel Role of Hematopoietic Stem Cells in Immunologic Rejection of Malignant Pediatric Brain Tumors
Catherine Flores, PhD
University of Florida
2015
The Effect of Locus of Care Upon Adolescent and Young Adults Cancer Outcomes: An IMPACT Cohort Study
Sumit Gupta, MD/PhD
Hospital for Sick Children
2015
A Translational Approach to Identify Drugs with Specific Activity Against EZH2 Mutant High Risk T-ALLs and ETP ALLs that Overexpress the JDP2 bZIP Transcription Factor
Shuning He, PhD
Dana-Farber Cancer Institute
2015
Critical Contributions of CRM1 to Leukemogenesis
Jessica Linda Heath, MD
University of Vermont
2014
Immunotherapy Of Neuroblastoma With Natural Killer T Cells Engineered To Target O-acetyl-GD2
Andras Heczey, MD
Baylor College of Medicine
2014
A Developmental Model to Characterize the Epigenetic Origins of the Retinoblastoma Tumor Initiating Cell
Jeffrey Huo, MD/PhD
The Johns Hopkins University School of Medicine
2014
Molecular Mechanism and Development of Therapeutic Strategies Targeting MYCN-induced Calcium Signaling in Advanced Neuroblastoma
Ingo Koomoa-Lange, PhD
University of Hawaii at Hilo
2014
Development of Targeted DNA-damaging Therapy for ATRX-deficient Pediatric Glioblastoma
Carl Koschmann, MD
University of Michigan
2014
Mechanisms of CNOT3 Tumor Suppression in T-ALL and Identification of New Drugs That Specifically Kill CNOT3-Deficient T-ALL Cells
Zhaodong Li, PhD
Dana-Farber Cancer Institute
2014
SETD2 Mutations in Prognosis and Chemotherapy Resistance in Relapsed Acute Lymphoblastic Leukemia
Brenton Mar, MD/PhD
Dana-Farber Cancer Institute
2014
Ca2+ Release Activated Ca2+ (CRAC) Channels in Control of Leukemic Cell Metabolism and Leukemia Stem Cell Maintenance in T-ALL
Mate Maus, PhD
New York University School of Medicine
2014
Autophagy and mTOR Inhibition in Pediatric Gliomas with BRAF Mutations
Jean Mulcahy Levy, MD
University of Colorado Denver
2014
Investigation of Oncogenic Long Non-coding RNAs in Ewing sarcoma
Siu Ping Ngok, PhD
Lucile Packard Children’s Hospital at Stanford University School of Medicine
2014
Translating BET Bromodomain Inhibitors for Acute Myeloid Leukemia Therapy
Yana Pikman, MD
Dana-Farber Cancer Institute
2014
Targeted Therapy for Core Binding Factor Leukemia
John Pulikkan, PhD
University of Massachusetts Medical School
2014
Deciphering the Mechanisms of Medulloblastoma Treatment Resistance using Integrative Genomics
Vijay Ramaswamy, MD
Hospital for Sick Children
2014
Understanding and Preventing Healthy Tissue Damage in Pediatric Cancer Patients
Kristopher Sarosiek, PhD
Dana-Farber Cancer Institute
2014
Targeting Aberrant Hh Signaling with BET Bromodomain Inhibition as a Novel Therapeutic Strategy Against MB and DIPG
Yujie Tang, PhD
Lucile Packard Children’s Hospital at Stanford University School of Medicine
2014
Identification of Resistance Mechanisms and Novel Therapeutic Strategies in Tyrosine Kinase Inhibitor Resistant FLT3/ITD Acute Myeloid Leukemia
Katherine Tarlock, MD
Fred Hutchinson Cancer Research Center
2014
Optimizing Engager T-cells for CD19+ Malignancies
Mireya Paulina Velasquez, MD
Baylor College of Medicine
2014
Hospital Volume and Induction Mortality in Children, Adolescents, and Young Adults with Acute Leukemia
Jennifer Wilkes, MD
Children’s Hospital of Philadelphia
2014
Exosomes as Biomarkers to Monitor Disease Progression and Response to Therapy in Ewing sarcoma
Glenson Samuel, MD
Children’s Mercy
2014
Targeting the Epigenome of Diffuse Intrinsic Pontine Glioma
Sama Ahsan, MD
The Johns Hopkins University School of Medicine
2014
Targeting the Thymic Stromal Lymphopoeitin Receptor Signaling Axis to Reduce Relapse of High Risk Pediatric Acute Lymphoblastic Leukemia
Christopher Chien, PhD
National Cancer Institute
2014
APOBEC3 in Pediatric Leukemia: a Biomarker for Sensitivity to PARP Inhibition?
Abby Green, MD
Children’s Hospital of Philadelphia
2014
Niche for in Vitro Generation of Hematopoietic Stem Cells from Pluripotent Stem Cells
Brandon Hadland, MD/PhD
Fred Hutchinson Cancer Research Center
2013
Genetic Dissection of Trisomy 21-TMD Using Human Pluripotent Stem Cells
Glenn MacLean
Boston Children’s Hospital
2013
Investigating the Role of Circadian Rhythm in the Progression of Acute Myeloid Leukemia
Samantha Morris, PhD
Boston Children’s Hospital
2013
Dissecting the Hierarchy of Tumor Cell Differentiation Using Dual Recombinase Technology in a Novel Mouse Model of Rhabdomyosarcoma
David Van Mater, MD/PhD
Duke University Medical Center
2013
Characterization of the Role of Chromosome 1p Deletion in MYCN-Amplified Neuroblastoma
Miller Huang, PhD
University of California San Francisco
2013
Targeted Inhibition of Signaling Networks in Pediatric Glioblastoma Stem Cells
Erin Simonds, PhD
University of California Berkeley
2013
Reversing the Oncogenic Roles of Misdirected Chromatin Remodeling in Synovial Sarcoma
Cigall Kadoch, PhD
Lucile Packard Children’s Hospital at Stanford University School of Medicine
2013
Genomic Alterations in ETV6 Predict Outcome in Pediatric AML
Heather Helton, MD
Fred Hutchinson Cancer Research Center
2013
Genetic Profiling and Experimental Modeling of High-risk Acute Lymphoblastic Leukemia
Kathryn Roberts, PhD
St. Jude Children’s Research Hospital
2013
Multifunctional Nanomaterials for the Prevention of Radiotherapy's Side Effects and Childhood Cancers
Charalambos Kaittanis, PhD
Massachusetts General Hospital
2013
Dissecting the Mechanism of Overgrowth and Tumorigenesis in Beckwith-Wiedemann Syndrome
Jennifer Kalish, MD/PhD
University of Pennsylvania
2013
The Regulation of Hematopoietic Stem Cell Function by Granulocyte-Colony Stimulating Factor
Laura Schuettpelz, MD/PhD
Washington University
2013
Dissecting and Targeting the Wnt Signaling Pathway in Metastatic Osteosarcoma
Jason T. Yustein, MD/PhD
Baylor College of Medicine
2013
PRL3 as a Novel Therapeutic Target for Relapsed T-cell Acute Lymphoblastic Leukemia
Jessica Blackburn, PhD
Massachusetts General Hospital
2013
LRP1 and Angiogenesis in Pediatric Malignant Glioma
Takahisa Kanekiyo, MD/PhD
Mayo Clinic Jacksonville
2013
Defining the Mechanism by which LIN28B acts as an Oncogene in Neuroblastoma
Robert Schnepp, MD/PhD
Children’s Hospital of Philadelphia
2013
The Role of Prmt1 in Osteosarcoma Initiation and Metastasis
Hao-Ru Hsu, PhD
Dana-Farber Cancer Institute
2013
The Role of PTPRD as a Tumor Suppressor in Neuroblastoma Pathogenesis
Shizhen Zhu, MD/PhD
Mayo Clinic
2013
Histone Modification and Hmgn1 Overexpression as Drivers of B-ALL with Polysomy 21
Andrew Lane, MD/PhD
Dana-Farber Cancer Institute
2013
Oncogenic Hedgehog Pathway Activation by a Putative Rho GTPase-Activating Protein
Jun Ni, PhD
Lucile Packard Children’s Hospital at Stanford University School of Medicine
2013
Epigenetic Regulation of T cell Activation and Immunotherapy
Brian Ladle, MD/PhD
The Johns Hopkins University School of Medicine
2012
Determinants of Testicular Germ Cell Tumor Platinum Sensitivity and Resistance
Paolo Abada
University of California, San Diego
2012
Development of An Innovative Treatment Strategy for Neuroblastoma and Other Pediatric Tumors: A Novel Phospholipid Ester Analogue and its Multifunctional Cancer-targeting Nanoconstruct
Mario Otto
University of Wisconsin - Madison
2012
Identifying Therapeutic Targets for MiT Associated Pediatric Cancers
Sean Landrette
Yale School of Medicine
2012
Small-molecule screening for novel pediatric glioma radiosensitizers.
Ranjit Bindra
Yale School of Medicine
2012
Development of Targeted Therapies in High Risk Childhood Acute Lymphoblastic Leukemia
Sarah Tasian
Children’s Hospital of Philadelphia
2012
Role of Myosin VI in Pediatric Glioma Proliferation and Invasion
Monalisa Mukherjea
University of Pennsylvania
2012
Transcriptome Sequencing (RNA-Seq) for Identification of Novel Markers of Disease Outcome and Therapeutic Targets in Acute Myeloid Leukemia
Fabiana Ostronoff, MD
Fred Hutchinson Cancer Research Center
2012
Exploiting WT1 Genomic Alterations for Target Identification and MRD Monitoring in Pediatric AML
Phoenix Ho
Fred Hutchinson Cancer Research Center
2012
Investigating the Role of the RNA Binding Protein LIN28 in Neuroblastoma
John Powers
Boston Children’s Hospital
2012
Selective inhibition of nuclear export as a novel therapeutic strategy in AML
Julia Etchin
Dana-Farber Cancer Institute
2012
SWI/SNF Complex and Glucocorticoid Resistance in Pediatric Acute Lymphoblastic Leukemia
Jennifer Wu
Dana-Farber Cancer Institute
2012
Epigenetic regulation of self-renewal pathways in hematopoietic and leukemic stem cells
Alexandros Tzatsos, MD/PhD
George Washington University
2012
Screening for New Rhabdomyosaroma Pathogenesis Genes in a Drosophila Model
Kathleen Galindo
University of Texas Southwestern Medical Center
2012
Treatment for human hepatoblastoma based on recombinant adeno-associated virus vectors
Chen Ling
University of Florida
2012
Adoptive Cell Therapy Targeting Antigen Escape Variants in Childhood High Grade Glioma
Meenakshi Hegde, MD
Baylor College of Medicine
2011
Engineering A Graft Versus Leukemia Effect into Cord Blood Transplant for Acute Lymphoblastic Leukemia
Rebecca Gardner
Fred Hutchinson Cancer Research Center
2011
Investigation of Genetic and Molecular Mechanisms of Second Malignant Neoplasms in a Mouse Model
Jean Nakamura
University of California San Francisco
2011
Telomeres and Telomerase in Pediatric Acute Myeloid Leukemia
Maria Gramatges
Baylor College of Medicine
2011
Targeting polycomb-mediated epigenetic silencing in T cell acute lymphoblastic leukemia
Emmanuel Volanakis
Vanderbilt University Medical Center
2011
Targeting the Mechanism of Differentiation Arrest in a Novel Model of Acute Leukemia
David Sykes
Massachusetts General Hospital
2011
Identification of Alveolar Rhabdomyosarcoma "Achilles' Heel"
Fernanda Arnaldez
National Cancer Institute
2011
Validation of microRNAs as valid targets in a pediatric sarcoma
Mark Hatley
University of Texas Southwestern Medical Center
2011
Altering master genetic regulators SNF5/INI1 and LIN28A to model and treat atypical teratoid/rhabdoid tumors
Eric H. Raabe, MD/PhD
The Johns Hopkins University School of Medicine
2011
Mechanisms of Oncogenic Transformation by TLX1/HOX11
Mark Chiang
University of Michigan
2011
Targeting HMGA1 in Childhood ALL
Amy M. Belton, PhD
The Johns Hopkins University School of Medicine
2011
Using zebrafish to model the molecular origins of pediatric myeloid malignancies and acute myeloid leukemia
Evisa Gjini
Dana-Farber Cancer Institute
2011
The Role of Mxi1 in the Modulation N-Myc Function in Neuroblastoma
Michael Armstrong
Duke University
2010
Targeted Polymeric Parthenolide Carriers to Treat Childhood AML
Danielle Benoit
University of Rochester
2010
Single Cell Signaling Profiles In High-Risk Pediatric Leukemia
Kara Davis
Stanford University
2010
The Role of DNA Methylation in Pediatric Cancer
Scott Diede
Fred Hutchinson Cancer Research Center
2010
The p53-Mad2-Genomic Stability Pathway in the Development of Childhood Malignancies
Pascal Duijf
Memorial Sloan-Kettering Cancer Center
2010
Identification of Novel Treatment Targets by Exploring the Interaction of Rhabdomyosarcoma-Associated Oncogenes with Cellular Context in a Mouse Model of Rhabdomyosarcoma
Simone Hettmer
Dana-Farber Cancer Institute
2010
MicroRNAs 100 and 125b in Ewing sarcoma
Paul Jedlicka
University of Colorado Denver
2010
TLE1 Tumor Suppressor as a Key Regulator of myc Induced Leukemia
Selvi Ramasamy
Massachusetts General Hospital
2010
Promoter Hypermethylation in MLL-Rearranged Leukemias: Biology and Therapeutic Targeting
Eric Schafer
The Johns Hopkins University School of Medicine
2010
Characterization and Targeting of Novel Activating BRAF Mutations in Pediatric Brain Tumors
Angela Waanders, MD, MPH
Children’s Hospital of Philadelphia
2010
Virotherapy on Primary Neuroblastoma Cells
Pin-Yi Wang
Cincinnati Children's Hospital Medical Center
2010
Identification and Characterization of an Epigenetic Program that Maintains the Self-Renewal of MLL Myeloid Leukemia Stem Cells
Hon-Kit Wong
Stanford University
2010
The role of PDE4B in Racial Disparities in Outcome of Childhood Acute Lymphoblastic Leukemia
Jun Yang
St. Jude Children’s Research Hospital
2010
The Role of Metabolism in MLL-AF9 Leukemia Initiation
Rushdia Yusuf
Massachusetts General Hospital
2009
DFMO-based combination therapy for the treatment of advanced stage neuroblastoma.
Dana-Lynn Koomoa
Cancer Research Center of Hawaii
2009
MLL-based chromosomal translocations in the pathogenesis of childhood leukemia.
Erin Guest
Children’s Mercy
2009
Immune Stimulatory Antigen Loaded Particles (ISAPS) for the Treatment of Solid Childhood Tumors
Suzanne Miles
Children’s National Medical Center
2009
Identification of proteins interacting with ALK in neuroblastoma.
Rani George
Dana-Farber Cancer Institute
2009
Genetic Regulators of ER Stress-induced Apoptosis in Pediatric Malignancies
Ujwal Pyati
Dana-Farber Cancer Institute
2009
Aberrant DNA methylation in Ewing sarcoma.
Scott Borinstein
Fred Hutchinson Cancer Research Center
2009
GSTM4, a novel target for treating Ewing sarcoma.
Wen Luo
Huntsman Cancer Institute
2009
Identification of FDA approved drugs with anti-tumor activity in rhabdomyosarcoma.
David Langenau, PhD
Massachusetts General Hospital
2009
Exploring a novel immunotherapy: cooperation of endogenous CD8+ t-cells and exogenous, allogeneic CD4+ t-cells.
Heather Symons
The Johns Hopkins University School of Medicine
2009
Identifying novel biomarkers for risk stratification in t-cell acute lymphoblastic leukemia (ALL).
Michelle Hermiston, MD/PhD
University of California San Francisco
2009
Optimizing EGFR targeted therapy in pediatric malignant glioma.
Theodore Nicolaides
University of California San Francisco
2008
Immunotherapeutic Targeting of Stem Cells in Pediatric Brain Tumors
Joseph Lasky
Harbor - UCLA Medical Center
2008
Identification and Validation of Differentiation Therapy for Osteosarcoma
Katherine Janeway, MD
Dana-Farber Cancer Institute
2008
Treatment of high-risk pediatric brain tumors with a CD133-targeted adenovirus in combination with temozolomide
Marta Alonso, PhD
University of Texas M.D. Anderson Cancer Center
2008
Development of Immunostimulatory DNA as a Novel Therapy in Pediatric Acute Lymphoblastic Leukemia
Alix Seif, MD, MPH
Children’s Hospital of Philadelphia
2008
Targeting HMGA1 in Pediatric T-cell Acute Lymphoblastic Leukemia
Joelle Hillion, PhD
The Johns Hopkins University School of Medicine
2008
Integration of Targeted New Agents with Chemotherapy 
Robin Norris, MD
Children’s Hospital of Philadelphia
2008
Reciprocal interactions between tumor killer dendritic cells and tumor-induced regulatory T lymphocytes
Nicolas Larmonier, PhD
University of Arizona
2008
MDM2 as an Effector of Hedgehog Signaling in Brain Development and Medulloblastoma
Susan Mendrysa, PhD
Purdue University
2008
A mouse model of Wilms' Tumor
Nabeel Bardeesy, PhD
Massachusetts General Hospital
2008
Genomic Alterations in Medulloblastoma
Shahab Asgharzadeh, MD
Children’s Hospital Los Angeles
2008
The TC3 Line, a Zebrafish Model of T-Cell Malignancy
Nathan Meeker, MD
Huntsman Cancer Institute
2008
Characterization and Targeting of p53 Ubiquitination in Neuroblastoma.
Eveline Barbieri, MD/PhD
Baylor College of Medicine
2008
Untangling the Matrix in Medulloblastoma
Duncan Stearns, MD
St. Christopher's Hospital for Children
2007
An Exploration of the Medulloblastoma and Glioblastoma Genomes: A Critical Analysis of Candidate Cancer Genes as Potential Molecular Targets for Diagnostics and Therapeutics
Will Parsons, MD/PhD
The Johns Hopkins University School of Medicine
2007
Immunotherapy for Osteosarcoma and Ewing sarcoma
Nabil Ahmed, MD, MSc
Baylor College of Medicine
2007
Generation of a novel oncolytic virus for treatment of pediatric brain tumors.
Balveen Kaur, PhD
The Ohio State University
2007
The Identification of Neuroblastoma Cancer Stem Cells.
Robert Cho
Stanford University
2007
Developing an accurate genetic model for rhabdomyosarcoma therapy
Dawn Chandler, PhD
Children’s Research Institute
2007
The Role of Inhibition of Apoptosis by C/EBPalpha and C/EBPalpha oncoproteins in AML.
Ido Paz-Priel, MD
The Johns Hopkins University School of Medicine
2007
Resistance to anti-angiogenic therapy in pediatric solid tumors.
Samuel Soffer, MD
Feinstein Institute for Medical Research - North Shore
2007
DNA methylation in medulloblastoma
Rajeev Vibhakar, MD/PhD, MPH
University of Colorado Denver
2007
Mechanisms of regulation of the PI#K/AKT pathway downstream of NOTCH1 in T-ALL.
Teresa Palomero, PhD
Columbia University
2007
E2A translocations in pediatric leukemia: developing new therapeutic targets
Bruce Fischer, MD
Children’s Hospital of Philadelphia
2007
The Role of PASG in Mediating Epigenetic Change and Outcome in AML.
Jason Farrar, MD
The Johns Hopkins University School of Medicine
2006
Modeling osteosarcoma to identify novel therapeutic targets.
Julien Sage, PhD
Stanford University
2006
Anti-Angiogenic Effects of BAI Proteins in Neuroblastoma
Naomi Balamuth, MD
Children’s Hospital of Philadelphia
2006
Pax3-FKHR targets that enable bypass of cellular senescence in rhabdomyosarcoma.
Corinne Mary Linardic, MD/PhD
Duke University Medical Center
2006
Assess the activity of ABT-737 as a single agent against neuroblastoma cell lines grown in cell culture
Theresa Harned, MD
Children’s Hospital Los Angeles
2006
MTG-16 Regulation by Phosphorylation
Michael Engel, MD/PhD
Vanderbilt University Medical Center
2006
Hedgehog & IGF Signaling through IRSI in Brain Development and Medulloblastoma
Anna Marie Kenney, PhD
Memorial Sloan-Kettering Cancer Center
2006
Mechanisms of leukocyte recruitment to the lung during idiopathic pneumonia syndrome following allogeneic bone marrow transplantation.
Sung Won Choi, MD
Regents of the University of Michigan
2006
Mary Beth Ross, MD/PhD
Research Institute at Nationwide Children's Hospital
2006
WIP1 Modulates Responsiveness of MB to Genotoxic Stress.
Robert Craig Castellino, MD
Aflac Cancer Center and Blood Disorders Service of Children’s Healthcare of Atlanta
2006
Mediators of Metastasis in Alveolar Rhabdomyosarcoma.
Koichi Nishijo, MD/PhD
University of Texas Health Science Center at San Antonio
Young Investigator Grant

Featured Hero

Alexandra (Alex) Scott

Alexandra "Alex" Scott was diagnosed with neuroblastoma shortly before her 1st birthday. By her 4th, she said she wanted to hold a lemonade stand to help other kids with cancer. Sadly, she passed away at 8 years old, but her memory and dream live on...
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