The Regents of the University of California, Irvine

The Regents of the University of California, Irvine

141 Innovation

Irvine, CA 92697

United States

Enhancing TKI Therapy in Ph-Like Leukemia

Leukemia, Acute Lymphoblastic Leukemia (ALL)

A cellular enzyme known as mTOR is a master regulator of metabolic adaptation that senses nutrients and growth factors to control different cell functions. Many cancer cells depend on mTOR activity to maintain survival. mTOR hyperactivity is associated with poor prognosis in various tumors, especially leukemias. mTOR activity can be reduced pharmacologically using different classes of inhibitors or by dietary interventions.

Intervention Development and Evaluation to Reduce Disparities in Quality of Life for Latino Families Impacted by Cancer

General Pediatric Cancer

Cancer health disparities extend to caregivers with numerous studies demonstrating that the traumatic stress of having a child with a chronic illness is associated with poorer health. This includes more frequent illnesses, increased health care costs, and higher rates of comorbid diseases. (1) Moreover, cancer health disparities are a high priority given documented disparities in low socio-economic status and racial/ethnic minority groups. In terms of caregivers, these disparities contribute to increased stress and negative physical health.

Alex's Lemonade Stand Foundation for Childhood Cancer