Background
Medulloblastomas are the most common malignant brain cancer in children and pose a treatment challenge. The Epstein lab discovered that PID1, a little-known gene discovered in 2006, is growth-suppressive in medulloblastomas, constituting the first link of PID1 to cancer. Increasing PID1 slows growth of medulloblastoma while downregulating PID1 accelerates it.
