Childhood Cancer

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The Role of PASG in Mediating Epigenetic Change and Outcome in AML.

The Johns Hopkins University School of Medicine
Jason Farrar, MD
Grant Type: 
Young Investigator Grants
Year Awarded: 
Type of Childhood Cancer: 
Leukemia, Acute Myeloid Leukemia (AML)
Project Description: 
To determine promoter and genome-wide patterns of methylation alterations in AML and high-risk sarcoma samples from known clinical/molecular subgroups. We hypothesize that tumor samples with known adverse prognostic features will have distinct regional changes in CpG methylation when compared to lower-risk counterpart samples. To test this hypothesis, we are developing novel methods to prepare detailed, genome-wide maps of methylation in high risk pediatric cancer samples using a novel method of enrichment of methylated followed by high-resolution genomic tiling microarray analysis.