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The Tumor Suppressive Role of LNK (SH2B3) in Acute Lymphoblastic Leukemia

Children’s Hospital of Philadelphia
Wei Tong, PhD
Grant Type: 
Innovation Grants
Year Awarded: 
Type of Childhood Cancer: 
Leukemia, Lymphoma
Project Description: 

Acute lymphoblastic leukemia (ALL) is the leading cause of cancer-related death in young people, and commonly has a poor outcome in adults. The high-risk ALL is a subtype of ALL that fare a high rate of relapse and mortality. Intriguingly, high-risk ALLs show increased signaling response to growth factors that results in uncontrolled cell proliferation.

Project Goal
This study focuses on a critical regulator of growth factor signaling pathway and also a novel tumor suppressor, to improve our understanding of the pathogenesis of childhood leukemias. Moreover, we aim to reveal new strategies to effectively target leukemic cells through our mechanistic studies.

"This ALSF grant allows me to continue and expand our current research program on childhood leukemia. This work represents a new direction for my laboratory and is not funded by federal agencies, which usually do not invest in research that takes bold new directions. Without funding from ALSF, this research would not have been possible. I am excited to carry out this new adventure and fully anticipate that our studies will advance the understanding of pediatric cancer etiology and raise the possibility of new treatments for these diseases." 6/2014


CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies