You are here

Baylor College of Medicine

6621 Fannin
Houston, TX 77030
United States

Mentor Name: Andras Heczey

Mentor Name: Robin Parihar

Mentor Name: Mark Zobeck

Mentor Name: Will Parsons

Brain tumors are the leading cause of cancer related death in children. Ependymoma is an aggressive pediatric brain tumor resistant to chemotherapy, with treatment limited to surgical resection and radiation.

Despite attempts to improve treatment over the last few decades, children with advanced neuroblastoma or muscle or bone sarcoma continue to die from their disease. New treatments are sorely needed. Therapies that utilize the immune system to fight cancer, such as use of immune cells called natural killer (NK) cells, have shown promise in the lab. Their ability to cure patients, however, has been limited by a powerful tumor environment that inhibits the immune system.

Despite great advances in the care of kids with cancer, it is still the leading cause of death by disease after infancy among children in the United States. In addition, 60% of cancer survivors suffer long-term side effects from their treatment. The main limit of traditional cancer treatments such as radiation and chemotherapy is that they not only kill cancer cells, they also affect healthy ones. A new mode of treatment called Cancer Immunotherapy unleashes the patient’s immune system to only target cancer cells while avoiding healthy ones.

Mentor: Dr. Philip Lupo

Mentor: Dr. Stephen Mack

In the United States, children fighting cancer rarely ever abandon care. Most will complete their cancer treatment. Many more children who get cancer in the United States survive. However, in poorer countries like Botswana and Malawi in Africa, many children with cancer do not finish treatment and die. In some countries in Africa, nearly half of children with cancer end up abandoning care. This is one of the reasons why most children with cancer in Africa die.

Pages