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Baylor College of Medicine

6621 Fannin
Houston, TX 77030
United States

Pediatric high-grade gliomas (pHGG) are very aggressive brain tumors with poor prognosis. Unfortunately, clinical trials in the last few decades have failed to produce treatments that work for this cancer. One of the reasons for the lack of good treatments is that not all cells in a tumor are equal, and current treatments are not able to kill the most important cells for pHGG. In fact, we now know that only some cells have the characteristics required to fuel tomorrow growth. We now have applied a technique that allows usto look at single cells in tumors.

Mentor Name: Philip Lupo

Mentor Name: Andras Heczey

Immunotherapy using genetically engineered special white blood cells has revolutionized the treatment of children and adults with blood cancers including leukemias and lymphomas. This strategy has great potential to cure children with solid cancers; however, these tumors use mechanisms to inhibit the engineered white blood cells. When engineered cells lose their functionality in solid tumors, their program changes in response to the cancer cells. In this application, we will introduce mini programs into tumor-redirected white blood cells with the goal of overcoming solid tumors.

Mentor Name: Andras Heczey

Mentor Name: Robin Parihar

Mentor Name: Mark Zobeck

Mentor Name: Will Parsons

Brain tumors are the leading cause of cancer related death in children. Ependymoma is an aggressive pediatric brain tumor resistant to chemotherapy, with treatment limited to surgical resection and radiation.

Despite attempts to improve treatment over the last few decades, children with advanced neuroblastoma or muscle or bone sarcoma continue to die from their disease. New treatments are sorely needed. Therapies that utilize the immune system to fight cancer, such as use of immune cells called natural killer (NK) cells, have shown promise in the lab. Their ability to cure patients, however, has been limited by a powerful tumor environment that inhibits the immune system.

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