Intrinsically disordered protein regions (IDRs), part of the “dark matter of biology”, are extremely abundant in the protein kingdom. How IDRs perform functions in the cell is not well understood due to a lack of tools to study them. Since numerous known disease mutations occur in IDRs, our lack of understanding of IDRs represents a major hurdle for developing therapeutics. My lab strives to understand how IDRs play a role in regulating gene transcription in the context of physiology and disease.
