Children’s Hospital Los Angeles

Children’s Hospital Los Angeles

4650 Sunset Blvd.

Los Angeles, CA 90027

United States

Studies on the Growth-suppressive Mechanism of PID1 in Childhood Medulloblastoma

Background

Due to the low cure rates and the many long-term effects of treatment for those cured the tumors of medulloblastoma take many lives each day. There is not enough good research and understanding of medulloblastoma biology to develop better therapies with less long term consequences.

Altered Cerebral Blood Flow after Pediatric Posterior Fossa Brain Tumor Treatment

Brain Tumors

Background

Single-cell RNA-seq Profiling of Transcriptional Transition States During Human Retinoblastoma

Retinoblastoma

Background

Retinoblastoma is a childhood ocular tumor initiated by the inactivation of the RB1 gene and subsequent loss of retinoblastoma protein (pRB). Although pRB loss is the key-initiating event, the molecular mechanisms controlling the transformation of a normal retinal cell into malignancy remain unclear.

Targeting PI3Kdelta in Childhood Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL)

The Samantha Hill Childhood Cancer Hero Reach Grant

Background

Although many children who are treated for acute lymphoblastic leukemia (ALL) are cured, a significant percentage are not, and when this happens the prognosis is grim. Therefore, we need new ideas for the treatment of relapsed ALL. Instead of targeting only the leukemia cells, we look at a wider target: the leukemia cells as well as the protective non-leukemia cells, which are located in the bone marrow and create a safe haven for ALL cells.

Antibody Targeted Natural Killer Cell-Derived Extracellular Vesicles for the Treatment of Childhood Acute Lymphoblastic Leukemia and Neuroblastoma

Neuroblastoma

Background

Enhancing Effectiveness of Immune Checkpoint Therapy in Neuroblastoma

Neuroblastoma

Background

Enhancing Neuroblastoma Immunogenicity through Epigenetic Modification and T Regulatory Cell Blockade

Neuroblastoma

Identification of Therapeutic Targets to Improve Outcomes For Pediatric Cancer Patients.

Brain Tumors

Role of Exosomic miRNAs in the Development of Drug Resistance in Neuroblastoma (NBL)

Neuroblastoma

Predicting Outcome for Patients with Metastatic Neuroblastoma by Analysis of Bone Marrow and Blood for a Neuroblastoma Gene Expression Signature

Neuroblastoma

Neuroblastoma develops in the nervous system outside the brain and already has spread at diagnosis, especially to bone marrow, in 50% of patients. It is the most common solid tumor in children after brain tumors. PROBLEM. Although treatment has improved for patients with widespread, high-risk disease, only 45% survive long-term. Failure frequently occurs because tumor cells survive and grow in bone marrow. Currently, a test is not available to accurately measure a wide range of tumor cells (100% - 0.0001%) in bone marrow and blood at diagnosis and during and after therapy.

Alex's Lemonade Stand Foundation for Childhood Cancer