Background
Certain brain cancers in children do not respond well to current treatment options. Newer therapies, like immunotherapy - which uses the body's own defenses (the immune system) as a "drug" for diseases - are particularly promising. However, these therapies are not readily applicable in the brain cancer setting. Brain cancers do not have any single identifying mark that the immune system can use to differentiate it from healthy organs, and the cancers themselves maintain an environment that is harmful to immune cells.