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Children’s Research Institute

Children's National Medical Center111 Michigan Ave NW
Washington, DC 20010
United States

Mentor Name: Jo Lynne Rokita

Children’s Research Institute

Mentor Name: Conrad Russell Cruz

Children’s Research Institute

Mentor: Dr. Conrad Russell Cruz

Background

T cells have been successfully used against hematologic malignancies, but currently are limited against brain tumors.

Background

Background

Certain brain cancers in children do not respond well to current treatment options. Newer therapies, like immunotherapy - which uses the body's own defenses (the immune system) as a "drug" for diseases - are particularly promising. However, these therapies are not readily applicable in the brain cancer setting. Brain cancers do not have any single identifying mark that the immune system can use to differentiate it from healthy organs, and the cancers themselves maintain an environment that is harmful to immune cells.

Co-Investigators: Leanne Embry, PhD, University of Texas Health Science Center and Robert Noll, PhD, University of Pittsburgh

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