Background
Atypical teratoid/rhabdoid (AT/RT) tumor is the most common brain tumor of infancy. The vast majority of these young children do not survive their disease. New therapies are desperately needed. We have identified activation of a protein known as choline kinase in AT/RT. We find that a drug called CK37 inhibits choline kinase in AT/RT and can kill tumor cells. We find that choline kinase also downregulates the mTOR pathway and the MAP kinase pathway in the dish. We have found that these pathways are upregulated in AT/RT in.
