Acute lymphoblastic leukemia (ALL) is the most common form of childhood leukemia and the leading cause of death in children with cancer. While therapy is often curative, ~10% of children will relapse with recurrent disease and abysmal outcomes. Unfortunately, recent efforts to increase the dose or frequency of standard therapy have failed to prevent relapse. Thus, we have reached the ceiling of efficacy for current therapy and new strategies are needed. Here, we take a novel approach by focusing on HMGA1 proteins as drivers of relapse in leukemia.
