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Mayo Clinic Jacksonville

4500 San Pablo Road
Jacksonville, FL 32224
United States

Malignant brain tumors are the most common cause of cancer-related death in children. The current standard of care treatment is often associated with lifelong cognitive and motor deficits and is almost inevitably followed by disease recurrence. Therapiesthat specifically and efficiently target tumor cells and minimize toxicity to normal cells are thus critical to the next generation of interventionsthat promise improved clinical outcomesfor children affected by these deadly diseases.

Background


Malignant glioma accounts for a significant amount of morbidity and mortality among children with brain tumors. However, there are still no curable therapies. The abnormally accelerated blood vessel formation is thought to be a key pathogenic event in malignant glioma.