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National Cancer Institute

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Bethesda, MD 20892-2440
United States

A Home Physical Activity Program to Improve Cognitive Late Effects in Children Treated with Radiation for Brain Tumors

Brain Tumors

Identification of Mechanisms of Resistance to Trametinib Monotherapy in PAX-fusion Negative Rhabdomyosarcoma

Rhabdomyosarcoma

Background

Targeted Inhibition of the DNA Damage Response Pathway: A Novel Intervention in the Treatment of Pediatric Leukemias

Leukemia, Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Lymphoma

Background

The most common form of cancer amongst children and teenagers is leukemia, a disease of the blood and bone marrow that accounts for nearly one out of three cancers in this age group. The specific sub-types of acute leukemias that are most widespread amongst children are ALL (Acute Lymphoblastic Leukemia) and AML (Acute Myeloid Leukemia). ALL and AML are types of leukemias where an individual's bone marrow produces too many white blood cells that fail to undergo proper maturation or differentiation.

Targeting the Thymic Stromal Lymphopoeitin Receptor Signaling Axis to Reduce Relapse of High Risk Pediatric Acute Lymphoblastic Leukemia

Leukemia

Background

Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Although the cure rate for this disease is greater than 85%, ALL remains a primary cause of cancer-related deaths in children due to relapse of disease. Importantly, there has been little progress in improving outcomes for patients with relapsed or refractory disease.

Identification of Alveolar Rhabdomyosarcoma "Achilles' Heel"

Rhabdomyosarcoma

Alveolar rhabdomyosarcoma is a malignant tumor that originates in the muscle. It mostly affects young children. Its treatment involves surgery, radiation and chemotherapy. These therapies have many side effects and are significantly toxic. Unfortunately, children with distant metastases and patients with recurrent disease have a very poor prognosis.

Featured Hero

Chris Ramirez

Chris loves baseball – he has a history of playing for his high school team and is a longtime fan of the San Francisco Giants. However, when he was in high school, Chris began having strange symptoms. Today, Chris is a three-time survivor of glioblastoma.
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