Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal pediatric brain cancer with no effective treatments, and most children survive less than a year after diagnosis. Chimeric Antigen Receptor (CAR) T cell therapy shows promise but struggles with brain tumor penetration, persistence, and immune suppression. This project focuses on gamma delta (?d) T cells, a rare immune cell type that naturally resists exhaustion, functions in the brain, and can kill cancer cells without traditional immune system signals.
The Regents of the University of Minnesota
600 McNamara Alumni Center S.E., 200 SE Oak St
Minneapolis, MN 55455
United States