Background: The cause of most childhood cancers remains a mystery. Even basic epidemiologic characteristics of children with cancer are not completely understood. Project Goal: This study seeks to describe where and when nearly every child with cancer in California for the last 30 years was born and diagnosed and to identify unusual patterns of disease occurrence and to ascertain if there are social disparities in childhood cancer. Methodology: Children with childhood cancers (25,518 cases) will be compared to healthy children (102,072 controls) drawn from the California Birth Cohort.