Alex's Lemonade Stand Foundation for Childhood Cancer

Medulloblastoma is the most common childhood brain cancer, forty percent of which is caused by activated Hedgehog (HH) or WNT signaling pathways. These two signaling pathways are also two of the most common pathways activated in cancer, providing the driving force for the growth and maintenance of cancer stem cells -- the cells proposed to be resistant to chemotherapy and radiotherapy that ultimately leads to cancer relapse. Thus the targeted attenuation of these signaling pathways could tremendously improve the outcome of such therapy.