University of Minnesota

University of Minnesota

420 Delaware Street SE

Minneapolis, MN 55455

United States

Late effects in pediatric germ cell tumor survivors

Germ Cell Tumor

Mentor Name: Jenny Poynter

Peripheral neuropathy in pediatric germ cell tumor survivors

Germ Cell Tumor

Mentor Name: Jenny Poynter

Genetic Susceptibility to Ototoxicity in Pediatric Germ Cell Tumor Survivors

Germ Cell Tumor

Lay Summary: Survival rates are high for germ cell tumors (GCTs) due to the effectiveness of platinum-based chemotherapy; however, we don’t know much about how treatment for GCT affects the health of survivors because they have not been included in previous childhood cancer survivor studies. Data from men with testicular GCT and from other childhood cancer survivors suggest that considerable late effects of cancer treatment are likely to exist, including second cancers, hearing loss, heart disease and infertility.

Epidemiology of Pediatric Germ Cell Tumors: Outcomes and Comparison of Incidence Rates

Germ Cell Tumor

Background

Germ cell tumors (GCT) are the second most common type of cancer from the ages of 15-19, and comprise 3.5% of all childhood cancers. Most children who are diagnosed with GCTs are cured; however, little is known about the long-term effects of treatment.

A Characterization of TP53 Mutations Among Pediatric Osteosarcoma Cases

Osteosarcoma

Background

Knowledge of the genetic contributions to osteosarcoma (OS) susceptibility is critical for improving patient outcomes by enabling early detection and disease prediction. Brandon's project will be to expand the literature on an important gene, TP53, by characterizing the distribution of its variants among osteosarcoma cases and further examining its relationship to genetically-determined growth.

Genomics of Pediatric Germ Cell Tumors

Germ Cell Tumor

Background

Pediatric germ cell tumors (GCTs) are cancers that affect approximately 600 children and adolescents per year in the United States; the incidence rates for some pediatric GCTs are rising. Little is known about why these types of cancers develop in children, but it is possible that abnormalities in underlying genetic processes that occur during fetal development play a role.

Development and Characterization of Novel Models of Human Osteosarcoma Development and Metastasis

Osteosarcoma

Enhancing Pediatric Sarcoma Immunotherapy by Drug Induced Expression of Tumor-Specific Cryptic Neoantigens

Osteosarcoma, Rhabdomyosarcoma

Alex's Lemonade Stand Foundation for Childhood Cancer