University of Texas M.D. Anderson Cancer Center

University of Texas M.D. Anderson Cancer Center

1515 Holcombe Blvd.

Houston, TX 77030

United States

Role of H3.3-G34R mutation in pediatric high-grade glioma

Pediatric brain tumors are the most common solid tumors in children, with approximately 5,000 new cases diagnosed per year in the United States. Around 17% of brain tumors in children age 0–14 years are pediatric high-grade gliomas (pHGGs). pHGG is the most lethal cancer in children; the median survival duration of children with HGG is only 12–15 months despite aggressive therapy.

Energy Balance Strategies for Decreasing Chemotherapy-Induced Cardiotoxicity

General Pediatric Cancer

Background

Advances in chemotherapy strategies have improved survival rates for childhood cancer to 80%. However, there are >400,000 survivors where cardiac disease related to cancer therapy is the leading cause of mortality. There is a correlation between total dose of doxorubicin (Dox) and overall survival in children with sarcomas but also a direct link between Dox dose and subsequent cardiac morbidity. We demonstrated that exercise during Dox decreased acute cardiac damage without interfering with Dox efficacy.

Targeting PLK1 as a Common Mechanism in Ph-like ALL

Acute Lymphoblastic Leukemia (ALL)

Background

As with many other cancers, acute lymphoblastic leukemia (ALL) cases are often driven by over-active proteins, called kinases. Although for some patients targeted therapy is available, many do not have appropriate agents available and many will not survive their disease. We are looking for common targetable pathways which are turned on by these kinases.

Adoptive immunotherapy using clinical-grade T cells.

Leukemia, Acute Lymphoblastic Leukemia (ALL)

Treatment of high-risk pediatric brain tumors with a CD133-targeted adenovirus in combination with temozolomide

Brain Tumors

Alex's Lemonade Stand Foundation for Childhood Cancer