Background
Synovial sarcoma (SS) remains a deadly soft-tissue malignancy with a predilection for younger patients. The tumor is associated in most cases with the SS18-SSX fusion oncogene. Our mouse models of synovial sarcomagenesis, driven by conditional expression of the human SS18-SSX cDNA, faithfully recapitulate characteristics of human SSs. They imply a causative role for SS18-SSX expression in SS.
