Rac in p190-BCR-ABL0Induced Leukemia.
Project Goals
We hypothesize that:
- Rac GTPases constitute a novel class of therapeutic targets in BCR- ABL-mediated leukemias;
- Specific BCR-ABL-dependent Rac activators cause the selective induction of lymphoid progenitor proliferation in p190 BCR-ABL+ ALL; and
- Since patient prognosis with p190 BCR/ABL+ ALL is extremely poor and these patients respond poorly to specific BCR-ABL tyrosine kinase inhibitors like imatinib, we believe that Rac may constitute a novel, significant molecular target in the therapy of p190-BCR/ABL+-ALL patients.
Progress Reports and Updates
Institutions
Project Type
Cancer Research Categories
Date Funded
2007
