The three specific aims of this project are to:
• Develop a tractable in vivo model for the monitoring of dynamic changes in neuroblastoma vascularization during tumor growth and in the context of chronic VEGF inhibition.
• Define optimal targets for synergistically enhancing the tumor growth delay mediated by anti-angiogenic effects of VEGF inhibition.
• Perform preclinical trials to define optimal dual angiogenesis inhibition strategies that are readily translatable to the clinic.