Childhood Cancer

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Nuclear Receptor Tyrosine Kinases Mediating Chromatin Remodeling & Checkpoint Adaption

Institution: 
Children's Cancer Therapy Development Institute
Researcher(s): 
Charles Keller, MD/PhD
Grant Type: 
Innovation Grants
Year Awarded: 
2018
Type of Childhood Cancer: 
Rhabdomyosarcoma
Project Description: 

Background
Alveolar rhabdomyosarcoma is a cancer of the soft tissues. This disease often responds to chemotherapy, but in many patients the available treatments fail – a deadly outcome. We identified how a cancer-causing fusion gene called Pax3:Foxo1 may lead to treatment failure: by turning on growth factor genes late in the process of tumor cell duplication. We believe this pro-growth, pro-survival process allows tumor cells to endure chemotherapy and radiation and allow tumor recurrences. 

Project Goal
For this project, learning how to better use growth factor inhibitors could pave the way to new designs of evidence-based clinical trials that prevent treatment relapse and could save lives.

Co-funded by: 
Northwestern Mutual Foundation