Background: There is an urgent need for improved and safer therapies for the treatment of children, adolescents and young adults (AYA) diagnosed with high-risk, pediatric cancers. Testing of new therapies for pediatric cancers requires an experienced network of clinical scientists, research nurses, investigational pharmacists, regulatory experts and data coordinators in order to manage early-phase clinical trials. Project Goal: To help meet the growing needs of the Pediatric Cancer Developmental Therapeutics (DVL) Program at Children's Hospital of Wisconsin, we are requesting funding for a Research Nurse to help organize, educate and oversee care of patients enrolled on early phase clinical trials. In addition, support for the dedicated time of an Investigational Pharmacist will ensure standardization and regulatory compliance with increasingly complex clinical trial requirements. Investment by Alex's Lemonade Stand Foundation (ALSF) will provide the necessary resources required to support investigator-initiated trials that are critical to increasing clinical trial opportunities to children, adolescents and young adults diagnosed with pediatric cancer in Wisconsin and throughout the upper Midwest.