Northwestern Mutual Foundation

The mission of the Northwestern Mutual Foundation is to improve the lives of children and families in need. The Foundation has given more than $35 million since its inception in 1992 and is designed to create lasting impact in the communities where the company's employees and financial representatives live and work. We accomplish this by combining financial support, volunteerism, thought leadership and convening community partners to deliver the best outcomes. Our efforts are focused nationally on curing childhood cancer, and locally on education, neighborhoods and making our hometown of Milwaukee a great destination.

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Co-Funded Projects

Project Title	Institutions	Co-Funder(s)
Leveraging oncogenic mutant-ATRX driven collateral vulnerabilities to identify novel therapeutic approaches	St. Jude Children’s Research Hospital	Northwestern Mutual Foundation
Characterizing determinants of response and therapeutic barriers to novel antibody-drug conjugates (ADCs) targeting the Anaplastic Lymphoma Kinase (ALK) oncoprotein in neuroblastoma	Children’s Hospital of Philadelphia	Northwestern Mutual Foundation
Enhancing CAR T Cell Therapy for Diffuse Intrinsic Pontine Glioma by Promoting CAR T Cell Persistence with Novel Manufacturing Approach and Immune Checkpoint Receptor Modifications	Seattle Children’s Hospital	Northwestern Mutual Foundation
Targeting KAT2A-Dependent Oncogenic Transcriptional Programs in Pediatric AML Using a Novel Molecular Glue Degrader	Dana-Farber Cancer Institute	Northwestern Mutual Foundation
Epigenetic Targeting of Translation in Sarcomas	Seattle Children’s Hospital	Northwestern Mutual Foundation
Investigating interactions between the oncogenic phosphatase PPM1D and oncohistone H3K27M in diffuse midline gliomagenesis	Duke University	Northwestern Mutual Foundation
Targeting Fatty Acid Oxidation as a Metabolic Vulnerability in Pediatric Cancers	Dana-Farber Cancer Institute	Northwestern Mutual Foundation
Identifying mechanisms of revumenib resistance in KMT2A-r pediatric acute myeloid leukemia (AML)	The Johns Hopkins University School of Medicine	Northwestern Mutual Foundation
The immunosuppressive role of thrombospondin-2 in pulmonary metastatic osteosarcoma	Children’s Hospital Los Angeles	Northwestern Mutual Foundation
Targeting Chromatin Remodelers to Enhance Neuroblastoma Differentiation Therapy	Dana-Farber Cancer Institute	Northwestern Mutual Foundation

Project Title

Institutions

Co-Funder(s)

Leveraging oncogenic mutant-ATRX driven collateral vulnerabilities to identify novel therapeutic approaches

St. Jude Children’s Research Hospital

Northwestern Mutual Foundation

Characterizing determinants of response and therapeutic barriers to novel antibody-drug conjugates (ADCs) targeting the Anaplastic Lymphoma Kinase (ALK) oncoprotein in neuroblastoma

Children’s Hospital of Philadelphia

Northwestern Mutual Foundation

Enhancing CAR T Cell Therapy for Diffuse Intrinsic Pontine Glioma by Promoting CAR T Cell Persistence with Novel Manufacturing Approach and Immune Checkpoint Receptor Modifications

Seattle Children’s Hospital

Northwestern Mutual Foundation