Effects of CNS Treatment on the Hippocampus
Acute lymphoblastic leukemia (ALL) is the most common pediatric tumor among children and adolescents in the United States. Central nervous system (CNS) treatment has significantly contributed to the dramatic improvement in long-term disease-free survival of these patients by preventing disease relapse in the brain. Unfortunately, CNS treatment is frequently associated with long-term cognitive and academic problems. Despite problems associated with CNS treatment, little is known about the mechanisms of injury to the hippocampus and even less is known about changes in expression of genes involved in responses to brain injury and cognitive abilities. The purpose of this research is to investigate the effects of methotrexate on the hippocampus. Findings may be used to develop therapeutic strategies to protect the brain from injury, promote synaptic plasticity, and improve cognitive outcomes among the ever increasing numbers of children who are long-term survivors of ALL.

