Brain tumors pose a significant challenge in pediatric oncology and are among the leading causes of cancer-related deaths in children in the United States. Among these, Pediatric High-Grade Gliomas (pHGG) make up about 10% of all brain and central nervous system tumors. These tumors are particularly aggressive and have a very poor prognosis. Patients with pHGG tumors like diffuse intrinsic pontine gliomas (DIPG) typically do not survive more than two years, and there are not many treatment options available for them.
