Childhood Cancer Research

Single-cell Pediatric Cancer Atlas Grant

ALSF seeks to build a Pediatric Cancer Atlas as an open resource for discovery with an initial goal of producing data that can be harmonized. ALSF seeks researchers to create datasets that profile pediatric cancers at a single-cell resolution level. Single-cell profiling can provide insights into the heterogeneity of cells in a tumor and the surrounding tumor microenvironment, as well as variability in the states of cancer cells, all of which can influence the cancer’s response to treatments. The budget for this award is $200,000 USD over one year.

This grant is no longer offered.

All Accelerator Programs All ALSF Funded Projects
2019
Single-cell Gene Expression and Cytosine Modification Profiling in Pediatric Central Nervous System Tumors
Brock Christensen, PhD
Dartmouth College
2019
Single-cell Atlas of Pediatric Osteosarcoma
Natalie Collins, MD/PhD
Dana-Farber Cancer Institute
2019
Profiling the Transcriptional Heterogeneity of Diverse Pediatric Solid Tumors
Michael Dyer, PhD, Xiang Chen, PhD
St. Jude Children’s Research Hospital
2019
Single-Cell Profiling of Acute Myeloid Leukemia for High-Resolution Chemo-immunotherapy Target Discovery
Charles Gawad, MD/PhD
Stanford University School of Medicine
2019
Single Cell RNA Sequencing of Pediatric High- and Low-Grade Gliomas
Adam Green, MD, Jean Mulcahy Levy, MD
University of Colorado Denver
2019
Single-cell Profiling of Childhood Acute Lymphoblastic Leukemia
Charles Mullighan, MBBS (Hons), MSc, MD, Jeffrey Klco, MD/PhD
St. Jude Children’s Research Hospital
2019
Single Nuclear RNA-seq and Spatial Transcriptomic Analysis of Anaplastic and Favorable Histology Wilms Tumor
Andrew Murphy, MD, Xiang Chen, PhD
St. Jude Children’s Research Hospital
2019
Dissecting Pediatric Brain Tumour Progression Using Single-nuclei Sequencing
Trevor Pugh, PhD
University Health Network
2019
Single-cell Profiling of Pediatric Bone Sarcomas
Alice Soragni, PhD
University of California, Los Angeles
2019
Single-cell Profiling of Early T-cell Precursor Acute Lymphoblastic Leukemia
David Teachey, MD, Kai Tan, PhD
Children’s Hospital of Philadelphia