ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
| Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
|---|---|---|---|---|
| A Genomics Driven Pluripotent Stem Cell Model of Infant Lymphoblastic Leukemia | Children's Mercy Hospital Kansas City / Meagan Vacek, DO | Catalyst Grants | 2023 | Missouri |
| Structure-guided de novo design of molecules that selectively target EWS-FLI1 | University of Texas Health Science Center at San Antonio / David Libich, PhD | Innovation Grants | 2023 | Texas |
| Inducing Neuroblastoma Differentiation In Vivo | University of Alabama at Birmingham / Ankur Saxena, PhD | Innovation Grants | 2023 | Alabama |
| Modulation of STING to enhance the efficacy of treatments for diffuse midline glioma | Duke University / Zachary Reitman, MD/PhD | 'A' Award Grants | 2023 | North Carolina |
| Uncovering the signaling mechanisms allowing medulloblastoma progenitor cells to orchestrate tumor relapse | Medical University of South Carolina / Jezabel Rodriguez Blanco, PhD | 'A' Award Grants | 2023 | South Carolina |
| A Cell Morphology Landscape of Pediatric Cancer Cell Lines | University of Colorado Denver_ Anschutz Medical Campus / Gregory Way, PhD | 'A' Award Grants | 2023 | Colorado |
| Synthetic gene expression regulator switches (SynGERS) expressed in CAR T cells to cure children with solid tumors | Baylor College of Medicine / Andras Heczey, MD | R Accelerated Award Grants | 2023 | Texas |
| Development of New Approaches to Target MAP Kinase Pathway in RAS-driven Rhabdomyosarcoma | University of Texas Health Science Center at San Antonio / Angelina Vaseva, PhD | R Accelerated Award Grants | 2023 | Texas |
| Unraveling the Function of PAX3-FOXO1’s Activation Domain in Rhabdomyosarcoma | Case Western Reserve University / Berkley Gryder, PhD | 'A' Award Grants | 2023 | Ohio |
| CLL-1 CAR-T cells with or without trametinib for the treatment of JMML | The Regents of the University of California San Francisco / Elliot Stieglitz, MD | R Accelerated Award Grants | 2023 | California |
| The Role of the Innate Immune System in Immune Dysregulation following CART | Children’s Hospital of Philadelphia / Caroline Diorio, MD | 'A' Award Grants | 2023 | Pennsylvania |
| Genomic and nuclear organizational changes in chemotherapy-resistant rhabdomyosarcoma cells | Ann & Robert H. Lurie Children’s Hospital of Chicago / Kyle MacQuarrie, MD/PhD | 'A' Award Grants | 2023 | Illinois |
| Activation of Anti-Leukemia Immunity by Targeting Protein Arginine Methyltransferase | City of Hope National Medical Center / Ling Li, PhD | R Accelerated Award Grants | 2023 | California |
| The role of pyruvate kinase as a therapeutic target in pediatric leukemia | Rutgers Cancer Institute of New Jersey / Daniel Herranz Benito, PhD | R Accelerated Award Grants | 2023 | New Jersey |
| Empowering specificity of AML immunotherapies by HSC engineering | Aflac Cancer Center and Blood Disorders Service of Children’s Healthcare of Atlanta / Pietro Genovese | Catalyst Grants | 2023 | Georgia |
| Empowering specificity of AML immunotherapies by HSC engineering | Boston Children’s Hospital / Pietro Genovese | Catalyst Grants | 2023 | Massachusetts |
| Development of a comprehensive liquid biopsy-based genomics platform for pediatric solid tumors | Children’s Hospital Los Angeles / Jaclyn Biegel | Catalyst Grants | 2023 | California |
| Circumventing Pediatric Solid Tumor Microenvironment Resistance by Combinatorial CAR NK and Immunomodulating Therapy | New York Medical College / Mitchell Cairo, MD | Reach Grants | 2023 | New York |
| Immunoglobulin High-Throughput Sequencing for Refining Risk Stratification in Infant B-ALL | University of Rochester / Carol Fries Simpson, MD | Reach Grants | 2023 | New York |
| Reversing Feedback Immunosuppression during Oncolytic Virotherapy of Pediatric High Grade Glioma | Augusta University Research Institute, Inc. / Bangxing Hong, PhD | Reach Grants | 2023 | Georgia |
| Feasibility Study of Dual Inhibition of MDM2 and Tubulin in Treatment of AML | Emory University / Muxiang Zhou, MD | Reach Grants | 2023 | Georgia |
| Identification of Aberrantly Methylated Differentially Expressed Genes to Distinguish High- vs. Low-Risk Retinoblastoma | Children’s Hospital Los Angeles / Jesse Berry, MD | Reach Grants | 2023 | California |
| The Impact of the Intestinal Microbiome on Sarcoma Metastasis | Albert Einstein College of Medicine / David Loeb, MD, PhD | Innovation Grants | 2023 | New York |
| Ectopic Neuroligin Signaling in Pediatric Glioblastoma | University of Utah / Alex Shcheglovitov, PhD | Innovation Grants | 2023 | Utah |
| Mechanisms to Redirect Tumor Associated Macrophages to Target Retinoblastoma Cells | The Regents of the University of Minnesota / Timothy Hallstrom, PhD | Innovation Grants | 2023 | Minnesota |
| Development of RADARS-based Therapy to Treat Fusion Molecule Driven Pediatric Malignancies | Boston Children’s Hospital / Alan B. Cantor, MD, PhD | Innovation Grants | 2023 | Massachusetts |
| Stapled Oncolytic Peptides for Treatment-Resistant Pediatric Leukemias | Dana-Farber Cancer Institute / Loren Walensky, MD, PhD | Innovation Grants | 2023 | Massachusetts |
| Targeting Chromatin Remodeling Complexes for Rhabdomyosarcoma (RMS) Therapy | Dana-Farber Cancer Institute / Jun Qi, PhD | Innovation Grants | 2023 | Massachusetts |
| CDK12 Links Radiation Response to PARPi Sensitivity in Pediatric Glioma | University of Colorado Denver_ Anschutz Medical Campus / Nathan Dahl, MD | Innovation Grants | 2023 | Colorado |
| Desmoplastic Small Round Cell Tumors: Investigation of its Pathogenesis and Development of Novel Therapies | Memorial Sloan-Kettering Cancer Center / Andrea Ventura, MD, PhD | Innovation Grants | 2023 | New York |
| Targeting Neurons in the Osteosarcoma Microenvironment with Non-Opioid Analgesic Lipid Nanoparticles | The Johns Hopkins University School of Medicine / Aaron James, MD, PhD | Innovation Grants | 2023 | Maryland |
| Novel Resilience Genes Required for Cerebellum Development and Medulloblastoma Survival | University of California San Francisco / Stephen Fancy, PhD, DVM | Innovation Grants | 2023 | California |
| In Situ CD19.CAR-T Generation Using TRIDENT System for Pediatric B Cell Malignancies | Baylor College of Medicine / Masataka Suzuki, PhD | Innovation Grants | 2023 | Texas |
| Targeting the Checkpoint Receptor TIGIT via CRISPR/Cas9 Genome Editing to Enhance NK Cell Anti-Tumor Activity | Research Institute at Nationwide Children's Hospital / Amanda Campbell, MD/PhD | Young Investigator Grants | 2023 | Ohio |
| Identifying Ewing Sarcoma Developmental Vulnerabilities | Children’s Hospital Los Angeles / Elena Vasileva, PhD | Young Investigator Grants | 2023 | California |
| Pre-Targeted Radioimmunotherapy for Desmoplastic Small Round Cell Tumors | Memorial Sloan-Kettering Cancer Center / Madelyn Espinosa-Cotton, PhD | Young Investigator Grants | 2023 | New York |
| Mechanisms of BRAF Activation in KIAA1549-BRAF Mutant pLGGs | Broad Institute / Sean Misek, PhD | Young Investigator Grants | 2023 | Massachusetts |
| CDK8 as a New Therapeutic Target in Alveolar Rhabdomyosarcoma | Dana-Farber Cancer Institute / Susu Zhang, PhD | Young Investigator Grants | 2023 | Massachusetts |
| Identifying Therapeutic Vulnerabilities in Pediatric AML through Investigation of the MECOM Transcriptional Network | Boston Children’s Hospital / Richard Voit, MD/PhD | Young Investigator Grants | 2023 | Massachusetts |
| Synthetic Gene Expression Regulatory Switches (SynGERS) for Improved CAR T Cell Function in Pediatric Solid Tumors | Baylor College of Medicine / Leidy Diana Caraballo Galva, PhD | Young Investigator Grants | 2023 | Texas |
| Radiation and the Tumor Microenvironment in an Immunocompetent Model of Ewing Sarcoma | Children’s Hospital of Pittsburgh Foundation / Jessica Daley, MD | Young Investigator Grants | 2023 | Pennsylvania |
| Elucidating the Roles of Aneuploidy in Down Syndrome-Associated Leukemia | Boston Children’s Hospital / Chun-Chin Chen, PhD | Young Investigator Grants | 2023 | Massachusetts |
| Arginine Depletion with DFMO in High-Risk Neuroblastoma | Children’s Hospital of Philadelphia / Christina Turn, MD | Young Investigator Grants | 2023 | Pennsylvania |
| A Novel Adjunctive LAT-Activating CART (ALA-CART) Cell Platform for the Treatment of Acute Leukemia | University of Colorado Denver_ Anschutz Medical Campus / Catherine Danis, PhD | Young Investigator Grants | 2023 | Colorado |
| Targeting Oncogenic N-MYC Complexes in High-Risk Neuroblastoma | The Regents of the University of California San Francisco / Bo Qiu, MD/PhD | Young Investigator Grants | 2023 | California |
| Ex Vivo Modeling of Medulloblastoma using Human iPSC-Derived Cerebellar Organoids | St. Jude Children’s Research Hospital / Stephanie Wu, PhD | Young Investigator Grants | 2023 | Tennessee |
| Creating an Infrastructure for Collaborative Clinical Research and Publication of Consensus Guidelines for RUNX1 Familial Platelet Disorder | The Cleveland Clinic Foundation / Brittany Stewart, PhD | RUNX1 Early Career Investigator Grants | 2023 | Ohio |
| Mutagenesis and disease progression in RUNX1 mutant blood stem cells is caused by inflammation-induced hyperactive signaling and supraphysiological mitochondrial ROS | St. Jude Children’s Research Hospital / Dirk Loeffler, PhD | RUNX1 Early Career Investigator Grants | 2023 | Tennessee |