ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
| Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
|---|---|---|---|---|
| Restoring RUNX1 Levels in FPD/AML | University of Washington, Seattle / Marshall Horwitz, MD/PhD | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2016 | Washington |
| Characterization of Pre-Leukemia Associated with Familial RUNX1 Mutations | Stanford University / Ravi Majeti, MD/PhD | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2016 | California |
| Identifying Therapeutic Targets to Prevent Progression of Familial RUNX1 Disorder to AML Using Novel iPSC Models | Icahn School of Medicine at Mount Sinai / Eirini Papapetrou, MD/PhD | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2016 | New York |
| Pharmacologic Enhancement of Residual Wild Type RUNX1 Protein Activity in FPD/AML | Boston Children’s Hospital / Alan Cantor, MD, PhD | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2016 | Massachusetts |
| Modeling RUNX1-Associated Clonal Hematopoietic Disorders in Zebrafish | Boston Children’s Hospital / Leonard Zon, MD | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2016 | Massachusetts |
| Web-Based Cognitive-Behavioral Treatment for Insomnia in Adolescent Cancer Survivors | Dana-Farber Cancer Institute / Eric Zhou, PhD | Psychosocial Grants | 2016 | Massachusetts |
| The Role of Affective and Cognitive-Executive Processes and Structural Brain Abnormalities on Social Adjustment in Pediatric Brain Tumor Survivors | University of Calgary / Fiona Schulte, PhD | Psychosocial Grants | 2016 | Alberta |
| Neurocognitive Outcomes in Survivors of Childhood Leukemia with Down Syndrome | St. Jude Children’s Research Hospital / Lisa Jacola, PhD | Psychosocial Grants | 2016 | Tennessee |
| Enhancing Coping and Communication in Children with Cancer and Their Parents: A Novel Internet-Based Intervention | Vanderbilt University Medical Center / Bruce Compas, PhD | Psychosocial Grants | 2016 | Tennessee |
| A Nurse-Led Structured Discharge Teaching Intervention for Parents of Newly Diagnosed Pediatric Oncology Patients | University of Alabama at Birmingham / Wendy Landier, RN/PhD | Nurse Researcher Grants | 2016 | Alabama |
| Altered Cerebral Blood Flow after Pediatric Posterior Fossa Brain Tumor Treatment | Children’s Hospital Los Angeles / Mary Baron Nelson, RN/PhD | Nurse Researcher Grants | 2016 | California |
| Role of Primary Cilium Signaling and Dynamics in Medulloblastoma Initiation and Progression | University of Texas Southwestern Medical Center / Saikat Mukhopadhyay, MD/PhD | 'A' Award Grants | 2016 | Texas |
| The Role of Inherited MLL3 Single Nucleotide Variants and Fetal Epigenetic Programming in Infant Leukemogenesis | Washington University / Jeffrey Magee, MD/PhD | 'A' Award Grants | 2016 | Missouri |
| Uncovering the Dysregulated RNA Binding Protein Network in Childhood Acute Myeloid Leukemia | Memorial Sloan-Kettering Cancer Center / Michael Kharas, PhD | 'A' Award Grants | 2016 | New York |
| Engineering the CAR T Cells to Overcome Tumor Derived Immune-Inhibition in Glioblastoma | Baylor College of Medicine / Meenakshi Hegde, MD | 'A' Award Grants | 2016 | Texas |
| An Engineered Nanoimmunotherapy for Treating Neuroblastoma | George Washington University / Rohan Fernandes, PhD | 'A' Award Grants | 2016 | District of Columbia |
| Detection of Circulating Tumor DNA in Pediatric Sarcomas | The Regents of the University of California San Francisco / Alejandro Sweet-Cordero, MD & Maximillian Diehn, MD/PhD (Stanford University) | Innovation Grants | 2016 | California |
| Improving Immune-Mediated Oncolytic Viral Therapy: Engineering Tumor Vaccine Elements into the Virus | Research Institute at Nationwide Children's Hospital / Kevin Cassady, MD & Christopher Walker, PhD | Innovation Grants | 2016 | Ohio |
| Developing and Distributing a Pediatric Spinal Cord High-grade Glioma Model | Stanford University / Michelle Monje, MD/PhD | Innovation Grants | 2016 | California |
| Preclinical Testing of Candidate Therapeutics in a Pediatric Spinal Cord High-grade Glioma Model | Stanford University / Michelle Monje, MD/PhD | Innovation Grants | 2016 | California |
| Astatine-211 Meta-Astatobenzylguanidine ([211At]MABG) Targeted Radiotherapy for Disseminated Neuroblastoma | Children’s Hospital of Philadelphia / John Maris, MD | Reach Grants | 2016 | Pennsylvania |
| DFMO Synergy with Chemo-immunotherapy to Eradicate MYC-Driven Neuroblastoma | Children’s Hospital of Philadelphia / Michael Hogarty, MD | Reach Grants | 2016 | Pennsylvania |
| LSD1 Inhibition to Treat T-cell Acute Lymphoblastic Leukemia/Lymphoma | University of Virginia, School of Medicine / Michael Engel, MD/PhD | Reach Grants | 2016 | Virginia |
| Targeting PLK1 as a Common Mechanism in Ph-like ALL | University of Texas M.D. Anderson Cancer Center / Joya Chandra, PhD | Reach Grants | 2016 | Texas |
| Enhancing Pediatric Sarcoma Immunotherapy by Drug Induced Expression of Tumor-Specific Cryptic Neoantigens | University of Minnesota / David Largaespada, PhD | Innovation Grants | 2016 | Minnesota |
| Image Guided Diffuse Intrinsic Pontine Glioma Drug Delivery and Design | Weill Cornell Medical College / Mark Souweidane, MD & Richard Ting, PhD | Innovation Grants | 2016 | New York |
| Redefining the Cellular Architecture of Diffuse Intrinsic Pontine Glioma through Large-Scale Single-cell RNA-seq Analyses | Massachusetts General Hospital / Mario Suva, MD/PhD | Innovation Grants | 2016 | Massachusetts |
| Circulating Exosomes as Biomarkers of Medulloblastoma Progression, Metastasis, and Recurrence | Weill Cornell Medical College / David Lyden, MD/PhD & Parveen Raju, MD/PhD | Innovation Grants | 2016 | New York |
| Child's Exposure to Radiation from Medical Imaging and the Risk of Childhood Leukemia: Pooled Analyses from the Childhood Leukemia International Consortium (CLIC) | University of California Berkeley / Catherine Metayer, MD/PhD & Steve Selvin, PhD | Epidemiology Grants | 2016 | California |
| Sepsis as innate immune stimulus: severe sepsis exposures and protection against relapse in children with acute leukemias | Children’s Hospital of Philadelphia / Alix Seif, MD | Epidemiology Grants | 2016 | Pennsylvania |
| Targeted Inhibition of Lin28/let-7 Binding to Treat Pediatric Malignancy | Boston Children’s Hospital / George Q. Daley, MD/PhD | Innovation Grants | 2016 | Massachusetts |
| GeneEditing in T cell Leukemia to Promote Immunomodulatory Forms of Cell Death | Boston Children’s Hospital / Dr. Ben Croker, PhD | Innovation Grants | 2016 | Massachusetts |
| Modeling Pediatric Spinal Gliomas Using Murine Spinal Neural Stem Cells | The Johns Hopkins University School of Medicine / Charles Eberhart, MD/PhD & Eric Raabe MD/PhD | Innovation Grants | 2016 | Maryland |
| DICER1-Driven Cancers: Models, Mechanisms and Therapies | University of Texas Southwestern Medical Center at Dallas / James Amatruda, MD/PhD | Innovation Grants | 2016 | Texas |
| Targeting Microenvironmental Support of Acute Lymphoblastic Leukemia | University of Rochester / Craig Mullen, MD/PhD | Innovation Grants | 2016 | New York |
| Development of an anti-KIR3DL1 Antibody to Promote Innate Immunity Against Neuroblastoma | Memorial Sloan-Kettering Cancer Center / Katherine Hsu, MD/PhD & Nai-Kong Cheung, MD/PhD | Innovation Grants | 2016 | New York |
| Enhancing Immunotherapy of Neuroblastoma | The Regents of the University of California, San Diego / Alice Yu, MD/PhD & Mitchell Diccianni, PhD | Innovation Grants | 2016 | California |
| MYC as a Driver and Anti-Cancer Target in Malignant Rhabdoid Tumors | Vanderbilt University Medical Center / William Tansey, PhD | Innovation Grants | 2016 | Tennessee |
| HOX Genes As Developmental Regulators Of Sarcomagenesis | University of Michigan / Elizabeth Lawlor, MD/PhD & Deneen Wellik, PhD | Innovation Grants | 2016 | Michigan |
| Targeted Combination Therapy to Sensitize High-Risk Acute Lymphoblastic Leukemia to Methotrexate via Restoration of Ikaros Tumor Suppression | The Pennsylvania State University / Sinisa Dovat, MD/PhD & Chunhua Song, MD/PhD | Innovation Grants | 2016 | Pennsylvania |
| Targeting the Function of Ezrin in Rhabdomyosarcoma | The Cleveland Clinic Foundation / Neetu Gupta, PhD & Peter Anderson, MD | Innovation Grants | 2016 | Ohio |
| CD47-blocking Oncolytic Vaccinia Viruses as Biotherapeutics for Pediatric Solid Tumors | St. Jude Children’s Research Hospital / Stephen Gottschalk, MD & Nino Rainusso, MD | Innovation Grants | 2016 | Tennessee |
| Pre-clinical Testing of Novel Glutamine Metabolic Inhibitors in MYC-driven Medulloblastoma | The Johns Hopkins University School of Medicine / Eric Raabe, MD/PhD & Dr. Barbara Slusher, PhD | Innovation Grants | 2016 | Maryland |
| Selective Epigenetic Regulation of Notch1 in T-cell Acute Lymphoblastic Leukemia | University of Michigan / Mark Yat-Fung Chiang, MD/PhD | Innovation Grants | 2016 | Michigan |
| Targeting MYCN-amplified Neuroblastoma Through RORalpha Activation | Baylor College of Medicine / Eveline Barbiere, MD | Innovation Grants | 2016 | Texas |
| Identification of Mechanisms of Resistance to Trametinib Monotherapy in PAX-fusion Negative Rhabdomyosarcoma | National Cancer Institute / Marielle Yohe, MD/PhD | Young Investigator Grants | 2016 | Maryland |
| Investigating Racial Disparities in Pediatric Acute Leukemia | University of California San Francisco / Lena Winestone, MD | Young Investigator Grants | 2016 | California |
| Targeting Eya2 to Inhibit c-Myc driven Medulloblastoma Tumor Progression | University of Colorado Denver / Melanie Vincent, PhD | Young Investigator Grants | 2016 | Colorado |
| A CRISPRi Genetic Screen in Ewing sarcoma Identifies a Novel Dependence on Homologous Recombination DNA Repair | University of California San Francisco / Asmin Tulpule, MD/PhD | Young Investigator Grants | 2016 | California |
| Resistance and Develop Improved Treatments for Relapsed/refractory Pediatric ALL | Dana-Farber Cancer Institute / Elizabeth Townsend, PhD | Young Investigator Grants | 2016 | Massachusetts |
| Bad Influence: EWS/FLI Alters LSD1 and NuRD Interactions to Enforce Oncogenic Function in Ewing’s | Research Institute at Nationwide Children's Hospital / Emily Theisen, PhD | Young Investigator Grants | 2016 | Ohio |
| The Role of ARID1A in Neuroblastoma Pathogenesis | Dana-Farber Cancer Institute / Hui Shi, PhD | Young Investigator Grants | 2016 | Massachusetts |
| Role of Kindlin-3 In Natural Killer Cell Mediated Tumor Killing | Children’s Hospital of Wisconsin - Milwaukee / Nathan Schloemer, MD | Young Investigator Grants | 2016 | Wisconsin |
| Elucidating the Role of Human FAN1 Nuclease in DNA Crosslink Repair | Yale School of Medicine / Timsi Rao, PhD | Young Investigator Grants | 2016 | Connecticut |
| Pre-clinical Evaluation of LSD1 Inhibitors for the Treatment of Pediatric Ewing sarcoma: Defining the Biomarkers of Sensitivity and Mechanisms of Resistance | Research Institute at Nationwide Children's Hospital / Kathleen Pishas, PhD | Young Investigator Grants | 2016 | Ohio |
| Interrogating the Enhancer Landscapes of Ependymoma to Inform Novel Therapies | Baylor College of Medicine / Stephen Mack, PhD | Young Investigator Grants | 2016 | Texas |
| Single-cell RNA-seq Profiling of Transcriptional Transition States During Human Retinoblastoma | Children’s Hospital Los Angeles / Sunhye Lee, PhD | Young Investigator Grants | 2016 | California |
| Genetically Engineered T Cells as Therapy for Pediatric Glioma | Baylor College of Medicine / Giedre Krenciute, PhD | Young Investigator Grants | 2016 | Texas |
| A Role for Non-canonical Wnt/PCP Signaling in Growth and Self-Renewal of Embryonal Rhabdomyosarcoma | Massachusetts General Hospital / Madeline Hayes, PhD | Young Investigator Grants | 2016 | Massachusetts |
| Variation in Care and Outcomes in Pediatric Acute Leukemia | Children’s Hospital of Philadelphia / Amanda DiNofia, MD | Young Investigator Grants | 2016 | Pennsylvania |
| Molecular Basis of ALK Inhibition Resistance in High-risk Neuroblastoma | Dana-Farber Cancer Institute / David Debruyne, PhD | Young Investigator Grants | 2016 | Massachusetts |
| The Role of MiRNA Impairment in Wilms' Tumor Formation | University of Texas Southwestern Medical Center at Dallas / Kenneth Chen, MD | Young Investigator Grants | 2016 | Texas |
| GPC2 as an Oncogene and Immunotherapeutic Target in High-risk Neuroblastoma | Children’s Hospital of Philadelphia / Kristopher Bosse, MD | Young Investigator Grants | 2016 | Pennsylvania |
| Developing Targeted Immunotherapy Against Pediatric Acute Myeloid Leukemia | Fred Hutchinson Cancer Research Center / Melinda Biernacki, MD | Young Investigator Grants | 2016 | Washington |
| Micro-environmental Regulators of Ewing sarcoma Metastasis | University of Pittsburgh / Kelly Bailey, MD/PhD | Young Investigator Grants | 2016 | Pennsylvania |
| CD19 Delta Ex2 Isoform as a Target for Alternative Therapies in Relapsed Pediatric B-ALL | Children’s Hospital of Philadelphia / Asen Bagashev, PhD | Young Investigator Grants | 2016 | Pennsylvania |
| Targeting Metabolism as a Therapeutic Approach for High-Risk MYCN-Driven Neuroblastoma | University of Pennsylvania / Nicole Anderson, PhD | Young Investigator Grants | 2016 | Pennsylvania |