Germ cell tumors arise from the tissues that make up the reproductive tract, and although rare, cause significant morbidity and mortality in the pediatric age group. This proposal will investigate the role of a gene called Lin-28 in germ cell tumors. Recently, we have discovered that Lin-28 blocks the production of an important class of regulators in the cell called let-7 microRNAs, which are "tumor-suppressors" that protect against cancers of the breast, lung, and colon.
Fighting childhood cancer, one cup at a time.
