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Children’s National Medical Center

111 Michigan Ave NW
Washington, DC 20010
United States

Pam HindThe National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE, version 4) is the standard lexicon for grading adverse events (AEs) experienced by pediatric cancer patients in oncology trials. The current standard in clinical trials is that all AEs are graded and reported by clinicians.

Current methods for treating tumors include surgery, chemo-therapy and radiation therapy. Immune therapy is a fourth dimension to cancer therapy that has great potential, but this potential is as yet unmet. We propose that a powerful immune response can be generated against a tumor by targeting specific cells of the immune system. These immune cells are involved in the immune response to fight "foreign bodies". We have evidence that specialized receptors and cells can be stimulated in the patient to shape the ideal immune response against a tumor.