Some childhood brain tumors can spread beyond the original tumor into the fluid surrounding the brain and spinal cord, called cerebrospinal fluid. This process, known as leptomeningeal metastasis, is one of the most serious complications of pediatric brain cancer. Once this spread occurs, treatment options are very limited, and survival is often measured in months. Current therapies, including radiation and chemotherapy, are not specifically designed to target this type of disease and can cause significant long-term side effects in children.





