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Massachusetts General Hospital

55 Fruit Street
Boston, MA 2114
United States

Rhabdomyosarcoma (RMS) is a common cancer found in children and young adults. This cancer shares many characteristics with muscle, and the most common type is called fusion-negative RMS (FN-RMS), which is the subject of my work. While patients with RMS often have good outcomes, those whose cancer has spread (metastasized) face a very poor prognosis, with less than 20% surviving. This highlights the urgent need to understand how RMS spreads and eventually kills patients.

Massachusetts General Hospital
Massachusetts General Hospital

Mentor Name: David Langenau

Rhabdomyosarcoma (RMS) is a common and aggressive childhood cancer that arises from muscle. Current treatment includes radiation, chemotherapy, and surgery. However, 30% of patients eventually develop resistance to the drugs used to treat their tumors and their tumors reform. Sadly, nearly all patients that develop therapy resistant RMS ultimately die of their tumors.

Mentor Name: David Langenau

Mentor Name: David Langenau

Fibrolamellar carcinoma is an liver cancer of adolescents and young adults. Currently the only effective treatment is surgery, but this is only possible in a subset of cases. Chemotherapy and targeted therapies have not been successful to date. Important features of this cancer include the presence of an abnormal gene in virtually every patient. This abnormal gene, referred to as DNAJB1-PRKACA, is found in virtually all patients.

Mentor: Bakhos Tannous

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