Massachusetts General Hospital

55 Fruit Street

Boston, MA 2114

United States

Molecular circuitry of fibrolamellar carcinoma

Fibrolamellar carcinoma is an liver cancer of adolescents and young adults. Currently the only effective treatment is surgery, but this is only possible in a subset of cases. Chemotherapy and targeted therapies have not been successful to date. Important features of this cancer include the presence of an abnormal gene in virtually every patient. This abnormal gene, referred to as DNAJB1-PRKACA, is found in virtually all patients.

Samaha Pediatric oncology student training (POST) program

Brain Tumors

Mentor: Bakhos Tannous

Olfactory Ensheathing Cells for Pediatric Glioma Gene/Cell Therapy

Glioma

Accessing Combinatorial Effect of PARP Inhibitor with DNA Damaging Agent in Rhabdomyosarcoma at Single Cell Resolution

Rhabdomyosarcoma

Mechanisms of OTX2 Mediated Chromatin Regulation in Medulloblastoma

Medulloblastoma

Generating Fusion-Positive Alveolar Rhabdomyosarcoma in Danio Rerio

Rhabdomyosarcoma

Background

Redefining the Cellular Architecture of Diffuse Intrinsic Pontine Glioma through Large-Scale Single-cell RNA-seq Analyses

Diffuse Intrinsic Pontine Glioma (DIPG)

Background

A Role for Non-canonical Wnt/PCP Signaling in Growth and Self-Renewal of Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma

Background

Identifying Epigenetic Mechanisms Impacting Neuroblastoma Genome Stability and Drug Response

Neuroblastoma

Background

Genome instability and drug resistance are hallmark features of cancer, especially neuroblastoma. We have recently uncovered the first enzyme KDM4A capable of generating site-specific copy gains of regions linked to drug resistance and hard to treat cancer, which provides a novel tool to carefully interrogate the molecular features affiliated with copy gains.

Anti-PIGF Therapy in Medulloblastoma

Brain Tumors, Medulloblastoma

Background

Medulloblastoma is the most common childhood brain tumor. It arises in the cerebellum, the part of the brain that controls coordination and movement. The standard treatment regimen consists of surgery, followed by a combination of intensive radiation and chemotherapy. Radiation therapy of the central nervous system in children is associated with severe side effects, including impaired cognitive function, neuroendocrine dysfunctions and secondary cancers. Currently, there is no treatment for resistant or relapsing tumors.

Alex's Lemonade Stand Foundation for Childhood Cancer