University of California, Los Angeles

University of California, Los Angeles

11000 Kinross Avenue

Suite 102

Los Angeles, CA 90095-1406

United States

In vivo transdermal generation of CD33 CAR T-cells towards acute myeloid leukemia

Pediatric acute myeloid leukemia (AML) is the second most common pediatric leukemia, with treatments still based on intense, conventional chemotherapy and overall survival remaining below 70%. Recently, therapeutic research has explored the engineering of a patient’s own immune cells to target unique AML cell surface markers. However to manufacture these therapies immune cells must be collected from patients whose immune system has been depleted by multiple rounds of chemotherapy.

Validating multifunctional extracellular vesicle magbeads as liquid biopsies for pediatric sarcomas

Osteosarcoma

Mentor Name: Steven Jonas

Evaluation of Nanotechnology Methods for Selective Capture of Ewing Sarcoma-derived CTCs and EVs

Ewing Sarcoma

Mentor: Steven Jonas

Pesticides and Childhood Central Nervous System Tumors

Brain Tumors

Mentor: Dr. Julia Heck

Single-cell Profiling of Pediatric Bone Sarcomas

Ewing Sarcoma, Osteosarcoma

Lay Summary: Each year in the U.S., about 1600 children and young adults are diagnosed with sarcoma--tumors affecting bones, muscle or cartilage. The majority of these are bone tumors, which include osteosarcoma (800 children diagnosed each year) and some Ewing sarcomas (250 cases each year). Bone sarcomas are rare, heterogeneous, and not yet fully characterized. Survival rates are in the 60% and as low as 20-30% for metastatic disease, and outcomes have not improved much over the past decade.

Maternal Comorbidities, Pharmaceutical Use and Childhood Cancers: A Record Linkage Study in Taiwan

General Pediatric Cancer

Background

In recent years there has been a growing recognition of the importance of maternal health during the preconception and pregnancy periods in the later health of children. Many mothers experience chronic or acute health conditions in the perinatal period and a few studies have linked certain conditions with increased pediatric cancer risk. Maternal health care may further involve the use of medications to treat a preexisting condition or a condition that develops during the prenatal period.

High-Throughput Gene-Editing via Microfluidic Cell Deformability to Enable Off-the-Shelf Allogeneic Cellular Immunotherapies

Leukemia

Develop a Therapeutic Vaccine Approach by Removing Viral Immune Evasion

Ewing Sarcoma, General Pediatric Cancer

Background

EBV and KSHV belong to the gamma subfamily of herpesviruses and are linked to a variety of human malignancies. For example, EBV is associated with Burkitt's lymphoma (BL), endemic to equatorial Africa where BL is the most frequent type of childhood malignancy. KSHV is associated with KS, which in children is aggressive and often results in rapid death. The risk of KS among individuals infected with human immunodeficiency-1 (HIV-1) is much higher than in un-infected people.

Pain and Symptom Experiences in Children with Cancer

General Pediatric Cancer

Alex's Lemonade Stand Foundation for Childhood Cancer